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  2. Dr Dan Stratton

Dr Dan Stratton

Profile summary

Professional biography

Degrees

PhD Immunology 2013

BSc (Hons) Biochemistry 2007

Brief Biography

I am an immunologist who has particular research interest in ageing/health span and cancer biology. I use extracellular vesicles and engineered proteins to investigate the control of tissues and cellular communication in cancer progression and immune mediated tissue modeling. 

Research interests

Research Clusters

Cancer Research

Global Health and Development

Research Interests

Cell communication, Extracellular Vesicels, Prognostics, Tissue repair/ageing and Protein design

Teaching interests

The body in balance SK190

Working title Immunity, Parasitology and Disease SK297

Impact and engagement

Selected Papers

Stratton, D., Malibha-Pinchbeck, M., Inal, J, (2022)  Extremely Low-Frequency Magnetic Fields significantly enhance the cytotoxicity of methotrexate and can reduce migration of cancer cell lines via transiently induced plasma membrane damage, Accepted BBRC

De Sousa, K. P., Rossi, I., Adbullahi, M., Ramirez, M. I., Stratton, D. and Inal, J. M. (2022) Isolation and characterization of extracellular vesicles and future directions in diagnosis and therapy, Accepted Nanomed Nanobiotecnol

Samireh Jorfi, Ephraim A. Ansa-Addo, Katia Marinello, Dan Stratton, Bridget E. Bax, Michelle Levene, Sigrun Lange and Jameel M. Inal., (2022) Coxsackievirus B1-mediated release of host cell microvesicles (MVs) reveals a nonlytic MV-to-cell mechanism of virus transmission, in preparation

Antwi-Baffour, S., Malibha-Pinchbeck, M., Stratton, D., Jorfi, S., Lange, S. and Inal J., (2020) Plasma mEV levels in Ghanain malaria patients with low parasitaemia are higher than those of healthy controls, raising the potential for parasite markers in mEVs as diagnostic targets, JEV, 9:1, 1697124

Elliot, B., Herbert, P., Sculthorpe, N., Grace, F., Stratton, D. and Hayes, L., (2017) Lifelong exercise, but not short-term high-intensity Interval Training, Increases GDFII, Marker of Successful Aging, Physiol. Reports, Vol. 5, pp 1-13

Aydar, E., Stratton, D., Fraser, S. P., Djamgoz, M. B. A and Palmer, C., (2016) Sigma-1 receptors modulate neonatal Na 1.5 ion channels in breast cancer cell lines, EBJO, 45 (7)

Hayes, L., Inal, J and Stratton, D., (2015) Re: Inflamed macrophage microvesicles induce insulin resistance in human adipocytes, Nutrition and Metabolism, Letter

Jorfi, S., Ansa-Addo, E.A., Kholia, S., Stratton, D., Valley, S., Lange, S. and Inal, J., (2015) Inhibition of microvesicles sensitizes prostate cancer cells to chemotherapy and reduces docetaxel dose required to limit tumor growth in vivo, Sci Rep, 5

Stratton, D., Moore, C., Antwi-Baffour, Lange, S. and Inal, J., (2015) Microvesicles released constitutively from prostate cancer cells differ biochemically and functionally to stimulated microvesicles released through sublytic C5b-9, BBRC, 460, pp589-95

Stratton, D., Lange, S., Kholia, S., Jorfi, S., Antwi-Baffour, S. and Inal. J., (2014) Label-free real-time acoustic sensing of microvesicle release from prostate cancer (PC3) cells using quartz crystal microbalance, Biochemical and Biophysical Research Communications, 452, pp 619-24

Inal, J.M., Kosgodage, U., Azam, S., Stratton, D., Antwi-Baffour, S. and Lange, S., (2013) Blood/plasma secretome and microvesicles, Biochim Biophys Acta, pp 2317-2325

Stratton, D., Lange, S. and Inal, J. M., (2013) Pulsed Extremely Low Frequency Magnetic Fields stimulate microvesicle release from human monocytic leukaemia cells, BBRC, pp 470-475

Inal, J. M., Stratton, D.,* Ansa-Addo, E.*, Kholia, S., Antwi-Baffour, S., Jorfi, S., and Lange, S. (2012) Microvesicles in Health and Disease, Archivum Immunologiae Therapiae et Experimentalis Vol. 60, pp 107-121

Grant, R., Stratton, D., Ansa-Addo, E., Antwi-Baffour, S., Jorfi, S., Kholia, S., Krige, L., Lange, S and Inal. J., (2011) A filtration-based protocol to isolate human Plasma Membrane-derived Vesicles and exosomes from blood plasma, Journal of Immunological Methods, Vol. 371, pp 143-151

Ansa-Addo, E. A., Lange, S., Stratton, D., Antwi-Baffour, S., Cestari, I., Ramirez, M. I., McCrossan, M. V. and Inal, J. M., (2010) Human plasma membrane-derived vesicles halt proliferation and induce differentiation of THP-1 acute monocytic leukaemia cells, J Immunol, pp 5236-5246

Publications

Extremely low-frequency magnetic fields significantly enhance the cytotoxicity of methotrexate and can reduce migration of cancer cell lines via transiently induced plasma membrane damage (2022-10-20)
Stratton, Dan; Malibha-Pinchbeck, Memory and Inal, Jameel
Biochemical and Biophysical Research Communications, 626 (pp. 192-199)


Isolation and characterization of extracellular vesicles and future directions in diagnosis and therapy (2022)
De Sousa, Karina P.; Rossi, Izadora; Abdullahi, Mahamed; Ramirez, Marcel Ivan; Stratton, Dan and Inal, Jameel Malhador
Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, Article e1835 ((Early access))