Cell & Molecular Biologist with 13+ years’ experience in Translational Research of which 7+ years supporting and consulting on academic Clinical Trial research – field of Pharmaceutical Medicine.
Areas of research emphasis in the field of translational science have been on chronic inflammatory conditions and combining knowledge of cellular & molecular signalling pathways with insights from structural biology and medicinal chemistry to investigate and characterise novel treatment interventions, primarily in the field of tumour growth & metastasis. Practical insights from clinical and pre-clinical laboratory research associated with university teaching hospitals on squamous cell carcinomas, pancreatitis, and role of epigenetics in gynaecological tumours.
Advanced training in Tumour Biology, Clinical Neuroscience, Human Physiology, Human & Animal Ethics, and Laboratory Animal Science (anaesthesia & analgesia, animal husbandry; FELASA category C - animal study director’s licence). Experience of handling and isolating primary cells from animal & human tissues, cell line cultures (mono and co-cultures, planar migration assays, chemotaxis assays, spheroid sprouting assays, transient and stable transfections), ex ovo chorioallontoic membrane (CAM) assays, mouse & rat tumour models, antibody production in rabbits, modification of small molecule inhibitors (SMIs) and peptides for systemic targeting using liposomal encapsulation or radionuclide coupling, Western blotting, PCR & qPCR, immunofluorescence microscopy; isolation, purification & characterisation of peptide molecules (single chain variable fragments: scFvs & design ankyrin repeat proteins: DARPins) using various biochemical assays and biophysical methods including: isothermal titration calorimetry (ITC), surface plasmon resonance (SPR) analysis, and size exclusion chromatography multi angle light scattering (SEC-MALS).
Psychologist with BPS Stage 1 training in Health Psychology and SDS Level 2 training in Cognitive Behavioural Therapy (CBT). Practical experience in piloting health interventions (increasing physical activity in elderly using a community science approach) with the aim of promoting life-style behaviour changes to support health & well-being for treatment interventions in the area of chronic non-communicable diseases such as COPD, rheumatoid arthritis, cardiovascular disease, obesity and mental health conditions. Clinical/research experience stemming from placements in Geriatric Neuropsychology (research into structural and functional implications of sexual dimorphism using MRI data; intervention to improve cognitive function in elderly depressed patients including design of a programme for visual perception disorders), as well as Childhood Autism (implications of early interventions and Applied Behavioural Analysis (ABA) teaching).
3+ years’ experience as active Committee Member and Social Media & Events Co-Lead for the Midlands Health Psychology Network (MHPN), supporting employability events (skill-based training and careers events), as well as knowledge exchange by organising seminars and an annual research conference for BSc & MSc Students and Trainee HP Practitioner Psychologists.
Roles within The Open University:
List of publications:
ORCID ID: https://orcid.org/0000-0002-9023-1456
Marine Natural Products with Activities against Prostate Cancer: Recent Discoveries (2023)
Montuori, Eleonora; Hyde, Caroline; Crea, Francesco; Golding, Jon and Lauritano, Chiara
International Journal of Molecular Sciences, 24, Article 1435(2)
ScFvs as Allosteric Inhibitors of VEGFR-2: Novel Tools to Harness VEGF Signaling (2018-05)
Ballmer-Hofer, Kurt; Hyde, Caroline A.C.; Schleier, Thomas and Avramovic, Dragana
International Journal of Molecular Sciences, 19, Article 1334(5)
Die extrazelluläre Inhibition des VEGF-Rezeptors-2 durch Antikörper-ähnliche Peptidmoleküle: Implikationen für die Tumortherapie (2012-12-12)
Hyde, Caroline Anna Clara and Ballmer-Hofer, Kurt
Swiss Medical Forum ‒ Schweizerisches Medizin-Forum, 12(50)
Targeting Extracellular Domains D4 and D7 of Vascular Endothelial Growth Factor Receptor 2 Reveals Allosteric Receptor Regulatory Sites (2012)
Hyde, Caroline A. C.; Giese, Alexandra; Stuttfeld, Edward; Abram Saliba, Johan; Villemagne, Denis; Schleier, Thomas; Binz, H. Kaspar and Ballmer-Hofer, Kurt
Molecular and Cellular Biology, 32(19) (pp. 3802-3813)
Epigenetics of ovarian cancer: From the lab to the clinic (2010-07)
Asadollahi, Reza; Hyde, Caroline A.C. and Zhong, Xiao Yan
Gynecologic Oncology, 118(1) (pp. 81-87)
Inhibition of arachidonic acid metabolism and its implication on cell proliferation and tumour-angiogenesis (2009-06)
Hyde, C.A.C. and Missailidis, S.
International Immunopharmacology, 9(6) (pp. 701-715)
Finding New Partnerships: The Function of Individual Extracellular Receptor Domains in Angiogenic Signalling by VEGF Receptors (2014-05-07)
Hyde, Caroline A. C.; Berger, Philipp and Ballmer-Hofer, Kurt
In: Feige, Jean-Jacques; Pagès, Gilles and Soncin, Fabrice eds. Molecular Mechanisms of Angiogenesis (pp. 47-75)
ISBN : 978-2-8178-0465-1 | Publisher : Springer | Published : Paris
Modulation of tumour angiogenesis by targeting p38 MAPK signalling in tumour-associated macrophages (2009-07-15)
Hyde, Caroline A. C.; Kumar, Sushil; Steiner, Rudolf and Schwendener, Reto A.
In : Molecular and Cellular Mechanisms of Angiogenesis (15-17 Jul 2009, University of Chester)