Dr Dan Stratton

Professional biography

Research Clusters

Cancer Research

Global Health and Development

Research Interests

Cell communication, Extracellular Vesicles (EVs), prognostics, lnc/miRNA, tissue modelling/ageing and protein design for cell communication.

Current research projects include examining EVs from Neuroendocrine Prostate Cancer in Hypoxic conditions. Examining Extra Low-Frequency Magnetic Fields effects as a potential cancer therapeutic treatment. EVs to modulate the Immunological response and tumour progression.

We are keen to collabororate.

Lecturer in Biomedical Health Sciences

Production/ Presentation;

The body in balance SK190

SDK100

SK297

SS032

S290

Post Graduate Supervision, Megan O'Neill doctoral researcher (Primary Supervisor PhD Student), Charles Makanjoula (Visiting Student)

Academic consultant for BBC2 Forensic - The Real CSI (2022 to date)

Pint of Science (19^th May 2019) ‘A brief guide to microvesicles’

Café Scientific (Sept 2019) The importance of science in forensic science (DNA)

BBC radio Humberside Breakfast Show (27^th September 2018) ‘Forensic science’

Sao Paulo Extracellular Vesicle workshop with invited talk, ‘Characterization of microvesicles' (2016)

Biomedical Sciences External Seminar Series, School of Life Sciences, The University of Hull (June 2017) ‘Microvesicles and cancer’.

London Extracellular Vesicle meeting (Feb 2017) ‘Using ELFMFs to generate MVs’.

Imperial University, Department of Chemical Biology and Biophysics (Oct 2013) ‘The joy of microvesicles’.

Gothenburg University, 1st ISEV conference (2012) ‘Microvesicle subtypes biochemistry and physiology differ depending upon stimuli’. 

Papers and Articles

Jorfi, S., Ansa-Addo, E., Mariniello, K., Warde, P., Senian, A. A. B., Stratton, D., Bax, B. E., Levene, M., Lange, S. and Inal, J. M. (2023) A coxsackie B1-mediated nonlytic Extracellular Vesicle-to-cell mechanism of virus transmission and its possible control through modulation of EV release, J Gen Virol, 104(9)

De Sousa, K. P., Rossi, I., Adbullahi, M., Ramirez, M. I., Stratton, D. and Inal, J. M. (2022) Isolation and characterization of extracellular vesicles and future directions in diagnosis and therapy, Nanobiotechnol.

Stratton, D., Malibha-Pinchbeck, M., Inal, J, (2022) Extra Low-Frequency Magnetic Field regime significantly enhances the cytotoxicity of methotrexate through transiently induced plasma membrane pores, Submitted BBRC

Antwi-Baffour, S., Malibha-Pinchbeck, M., Stratton, D., Jorfi, S., Lange, S. and Inal J., (2020) Plasma mEV levels in Ghanain malaria patients with low parasitaemia are higher than those of healthy controls, raising the potential for parasite markers in mEVs as diagnostic targets, JEV, 9:1, 1697124

Sellami M, Gasmi M, Denham J, Hayes LD, Stratton D, Padulo J, Bragazzi N., (2018) Effects of Acute and Chronic Exercise on Immunological Parameters in the Elderly Aged: Can Physical Activity Counteract the Effects of Aging? Front Immunol. 10;9:2187. doi: 10.3389/fimmu.2018.02187. PMID: 30364079; PMCID: PMC6191490.

Elliot, B., Herbert, P., Sculthorpe, N., Grace, F., Stratton, D. and Hayes, L., (2017) Lifelong exercise, but not short-term high-intensity Interval Training, Increases GDFII, Marker of Successful Aging, Physiol. Reports, Vol. 5, pp 1-13

Aydar, E., Stratton, D., Fraser, S. P., Djamgoz, M. B. A and Palmer, C., (2016) Sigma-1 receptors modulate neonatal Na 1.5 ion channels in breast cancer cell lines, EBJO, 45 (7)

Hayes, L., Inal, J and Stratton, D., (2015) Re: Inflamed macrophage microvesicles induce insulin resistance in human adipocytes, Nutrition and Metabolism, Letter

Jorfi, S., Ansa-Addo, E.A., Kholia, S., Stratton, D., Valley, S., Lange, S. and Inal, J., (2015) Inhibition of microvesicles sensitizes prostate cancer cells to chemotherapy and reduces docetaxel dose required to limit tumor growth in vivo, Sci Rep, 5

Stratton D, Moore C, Zheng L, Lange S, Inal J., (2015) Prostate cancer cells stimulated by calcium-mediated activation of protein kinase C undergo a refractory period before re-releasing calcium-bearing microvesicles. BBRC 8;460(3), pp511-7. doi: 10.1016/j.bbrc.2015.03.061. Epub 2015 Mar 19. PMID: 25797625.

Stratton, D., Moore, C., Antwi-Baffour, Lange, S. and Inal, J., (2015) Microvesicles released constitutively from prostate cancer cells differ biochemically and functionally to stimulated microvesicles released through sublytic C5b-9, BBRC, 460, pp589-95

Stratton, D., Lange, S., Kholia, S., Jorfi, S., Antwi-Baffour, S. and Inal. J., (2014) Label-free real-time acoustic sensing of microvesicle release from prostate cancer (PC3) cells using quartz crystal microbalance, Biochemical and Biophysical Research Communications, 452, pp 619-24

Inal, J.M., Kosgodage, U., Azam, S., Stratton, D., Antwi-Baffour, S. and Lange, S., (2013) Blood/plasma secretome and microvesicles, Biochim Biophys Acta, pp 2317-2325

Stratton, D., Lange, S. and Inal, J. M., (2013) Pulsed Extremely Low Frequency Magnetic Fields stimulate microvesicle release from human monocytic leukaemia cells, BBRC, pp 470-475

Inal, J. M., Stratton, D.,* Ansa-Addo, E.*, Kholia, S., Antwi-Baffour, S., Jorfi, S., and Lange, S. (2012) Microvesicles in Health and Disease, Archivum Immunologiae Therapiae et Experimentalis Vol. 60, pp 107-121

Grant, R., Stratton, D., Ansa-Addo, E., Antwi-Baffour, S., Jorfi, S., Kholia, S., Krige, L., Lange, S and Inal. J., (2011) A filtration-based protocol to isolate human Plasma Membrane-derived Vesicles and exosomes from blood plasma, Journal of Immunological Methods, Vol. 371, pp 143-151

Ansa-Addo, E. A., Lange, S., Stratton, D., Antwi-Baffour, S., Cestari, I., Ramirez, M. I., McCrossan, M. V. and Inal, J. M., (2010) Human plasma membrane-derived vesicles halt proliferation and induce differentiation of THP-1 acute monocytic leukaemia cells, J Immunol, pp 5236-5246

Prof Jameel Inal, School of Human Science, London Metropolitan University, UK

Prof Sigrun Lange, Life Sciences, University of Westminster, UK

Prof Sam Antwi-Baffour, the School of Biomedical and Allied Health Sciences, University of Ghana

Dr Lawrence Hayes, School of Health and Life Sciences, University of West Scotland, Scotland

Dr Leigh Madden, Faculty of Health Science, University of Hull, UK