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Dr Martin Bootman

Profile summary

  • Central Academic Staff
  • Reader in Biomedicine
  • Faculty of Science, Technology, Engineering & Mathematics
  • School of Life, Health & Chemical Sciences
  • martin.bootman

Externally funded projects

NMDA receptor targeting: a new therapeutic strategy for incurable prostate cancers
RoleStart dateEnd dateFunding source
Lead01 Oct 202130 Sep 2025Belgian Volition SRL

Recent genomic and histopathological analyses have shown that up to 17% of castration-resistant prostate adenocarcinomas (PCas) develop neuroendocrine (NE) features [1]. This trans-differentiation induces complete androgen-independence and promotes metastatic spreading. NE-PCas are currently incurable and associated with a dismal prognosis (median survival shorter than 1 year). Therefore, there is a dire need for the identification of effective therapeutic targets for this aggressive malignancy. Calcium dynamics govern key aspects of cellular phenotypes, including tissue specification, motility and proliferation. Notably, calcium-dependent alterations are reversible and targetable by small molecule inhibitors. Increasing evidence suggests that the alteration of calcium dynamics affects the initiation and progression of some malignancies. For example, we have shown that T-type calcium channels drive the proliferation of castration-resistant PCa [2]. However, the calcium signalling toolkit is organised in a complex network of interacting molecules. This interactome has never been explored systematically in the context of a specific malignancy. In this project, we propose to study the role of calcium-dependent genes in NE-PCa pathogenesis, with the ultimate goal of identifying new therapeutic targets

NMDA receptor targeting: a new therapeutic strategy for incurable prostate cancers
RoleStart dateEnd dateFunding source
Lead01 Oct 202130 Sep 2025Fraser McDonald

Recent genomic and histopathological analyses have shown that up to 17% of castration-resistant prostate adenocarcinomas (PCas) develop neuroendocrine (NE) features [1]. This trans-differentiation induces complete androgen-independence and promotes metastatic spreading. NE-PCas are currently incurable and associated with a dismal prognosis (median survival shorter than 1 year). Therefore, there is a dire need for the identification of effective therapeutic targets for this aggressive malignancy. Calcium dynamics govern key aspects of cellular phenotypes, including tissue specification, motility and proliferation. Notably, calcium-dependent alterations are reversible and targetable by small molecule inhibitors. Increasing evidence suggests that the alteration of calcium dynamics affects the initiation and progression of some malignancies. For example, we have shown that T-type calcium channels drive the proliferation of castration-resistant PCa [2]. However, the calcium signalling toolkit is organised in a complex network of interacting molecules. This interactome has never been explored systematically in the context of a specific malignancy. In this project, we propose to study the role of calcium-dependent genes in NE-PCa pathogenesis, with the ultimate goal of identifying new therapeutic targets.

Optimising a novel co-culture system to study cardiomyocyte-epicardial adipocyte interactions
RoleStart dateEnd dateFunding source
Co-investigator01 Feb 201831 Jan 2019The Biochemical Society

‘The Biochemical Society’s Eric Reid Fund for methodological development. The grant is to optimise development of a functional coculture of adipocytes and cardiomyocytes.’

Development of a proangiogenic tissue matrix regenerative scaffold
RoleStart dateEnd dateFunding source
Lead01 Jul 201630 Jun 2019Regenero Consorcio Regenero

Creation and development of a fibrin-based pro-angiogenic tissue matrix type scaffold. The goal is optimise the strutcure of the material to support mesenchymal stem cell pro-angiogenic and immuno-modulatory function for dermal and connective tissue reconstruction of chronic ulcers. The project involves a collaboration between the OU, the Institute of Biomedical Engineering at UCL (UCL IBME) and Cells for Cells, a Chilean Cell therapy company (C4C) spun out from University of Los Andes (UANDES) managed by a grant adminstration compay, Regenero.

Altered calcium homeostasis in Crohn's Disease
RoleStart dateEnd dateFunding source
Lead01 Oct 201530 Sep 2019Fraser McDonald;MRC Human Nutrition Research (MRC HNR)

This is a collaborative project with the MRC Human Nutrition Research Unit in Cambridge. They have a long-standing interest in understanding how peptidoglycans released by bacteria in the gut lead to dampening of immune responses. The current hypothesis suggests that the peptidoglycans are transported across the gut wall through specialized uptake cells because they are encased in a calcium-phosphate matrix. Following their transport across the gut wall, the peptidoglycan/calcium-phosphate nanoparticles are endocytosed by white blood cells that consequently express a death receptor ligand. This study will investigate the role of the mineral component of the peptidoglycan/calcium-phosphate nanoparticles, and examine whether Crohn's patients have a different response to normal, in that they cannot process the calcium deposit and it leads to abnormal cell function.

Altered Calcium Homeostasis In Crohn's Disease
RoleStart dateEnd dateFunding source
Lead01 Oct 201531 Jul 2021Fraser McDonald

This is a collaborative project with the MRC Human Nutrition Research Unit in Cambridge. They have a long-standing interest in understanding how peptidoglycans released by bacteria in the gut lead to dampening of immune responses. The current hypothesis suggests that the peptidoglycans are transported across the gut wall through specialized uptake cells because they are encased in a calcium-phosphate matrix. Following their transport across the gut wall, the peptidoglycan/calcium-phosphate nanoparticles are endocytosed by white blood cells that consequently express a death receptor ligand. This study will investigate the role of the mineral component of the peptidoglycan/calcium-phosphate nanoparticles, and examine whether Crohn's patients have a different response to normal, in that they cannot process the calcium deposit and it leads to abnormal cell function. (This record is supplementary to AMS record 171480 which covers the original studentship. Due to the withdrawal of a second student, we are recruiting a third - Fraser McDonald has agreed to fund the 1 year stipend shortfall at £14,553).

Characterising The Response Of Foamy Alveolar Macrophages To Inhaled Drug Particulates - Phase II
RoleStart dateEnd dateFunding source
Lead16 Jan 201515 Jan 2018NC3Rs (National Centre for the Replacement Refinement and Reduction of Animals in Research)

Lung diseases such as asthma and chronic obstructive pulmonary disease (COPD) affect the lives of millions of people in the UK. Whilst the number of patients diagnosed with lung disease increases each year, the treatments available have changed very little over the past 30 years, despite large investment from pharmaceutical companies for the development of new treatments. One of the main reasons that many new medicines have not reached the market is the limited understanding of how the immune system in the lungs responds to the inhalation of therapeutic drug powders. Additionally, current methods used to test the safety of new inhaled medicines, rely on animal models which may not accurately predict safety in humans. Regulatory bodies are therefore unable to approve new medicines that appear to sensitise the immune system in animal models, despite not knowing fully if these observations are adverse in human patients. This project aims to better characterise inflammatory responses in the lung to inhaled medicines. Commercially available cell based models of the lung will be used, and imaging, biological and analytical tools will be employed to determine the reactions to inhaled medicines. The ultimate goal will be to use non-animal methods to provide an in depth understanding of the immune responses in the lung to reduce the numbers of animal experiments required to achieve an accurate prediction of the safety of new inhaled medicines in humans.

Publications

Tetrameric, active PKM2 inhibits IP3 receptors, potentially requiring GRP75 as an additional interaction partner (2024-10)
Lemos, Fernanda O.; de Ridder, Ian; Wagner, Larry; Bootman, Martin D.; Bultynck, Geert; Yule, David I. and Parys, Jan B.
Biochimica et biophysica acta. Molecular cell research, 1871, Article 119796(7)

Sustainability in a broad sense: An essential aspect of scientific conferences (2024-07)
Brohus, Malene; Bootman, Martin D. and Bultynck, Geert
BioEssays, 46, Article 2400017(7)

Cellular effects of BAPTA: Are they only about Ca2+ chelation? (2024-02)
Sneyers, Flore; Speelman-Rooms, Femke; Verhelst, Steven H L; Bootman, Martin D. and Bultynck, Geert
Biochimica et biophysica acta. Molecular cell research, 1871, Article 119589(2)

The Roles of Transient Receptor Potential (TRP) Channels Underlying Aberrant Calcium Signaling in Blood-Retinal Barrier Dysfunction (2024)
Dragoni, Silvia; Moccia, Francesco and Bootman, Martin D.
Cold Spring Harbor Perspectives in Biology ((Early access))

The Complex Effects of PKM2 and PKM2:IP3R Disruption on Intracellular Ca2+ Handling and Cellular Functions (2023-10-26)
Lemos, Fernanda O.; de Ridder, Ian; Bootman, Martin D.; Bultynck, Geert and Parys, Jan B.
Cells, 12, Article 2527(21)

Intracellular BAPTA directly inhibits PFKFB3, thereby impeding mTORC1-driven Mcl-1 translation and killing MCL-1-addicted cancer cells (2023-09-08)
Sneyers, Flore; Kerkhofs, Martijn; Speelman-Rooms, Femke; Welkenhuyzen, Kirsten; La Rovere, Rita; Shemy, Ahmed; Voet, Arnout; Eelen, Guy; Dewerchin, Mieke; Tait, Stephen W. G.; Ghesquière, Bart; Bootman, Martin D. and Bultynck, Geert
Cell Death & Disease, 14, Article 600

Calcium signalling pathways in prostate cancer initiation and progression (2023-09)
Silvestri, Roberto; Nicolì, Vanessa; Gangadharannambiar, Priyadarsini; Crea, Francesco and Bootman, Martin D.
Nature reviews. Urology, 20 (pp. 524-543)

The roles of Transient Receptor Potential (TRP) channels and aberrant calcium signalling in blood-retinal barrier dysfunction (2023)
Dragoni, Silvia; Moccia, Francesco and Bootman, Martin D.
Communications Biology [Submitted to]

Off-target inhibition of NGLY1 by the polycaspase inhibitor Z-VAD-fmk induces cellular autophagy (2022-06-07)
Needs, Sarah H.; Bootman, Martin D.; Grotzke, Jeff E.; Kramer, Holger B. and Allman, Sarah A.
The FEBS Journal, 289(11) (pp. 3115-3131)

A non-canonical role for pyruvate kinase M2 as a functional modulator of Ca2+ signalling through IP3 receptors (2022-04)
Lavik, Andrew R.; McColl, Karen S.; Lemos, Fernanda O.; Kerkhofs, Martijn; Zhong, Fei; Harr, Michael; Schlatzer, Daniela; Hamada, Kozo; Mikoshiba, Katsuhiko; Crea, Francesco; Bultynck, Geert; Bootman, Martin D.; Parys, Jan B. and Distelhorst, Clark W.
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1869, Article 119206(4)

Quantal leaps in understanding Ca 2+ signaling: A “Taylored” approach (2022)
Patel, Sandip; Bootman, Martin D.; Rossi, Ana; Rahman, Taufiq and Marchant, Jonathan S.
Science Signaling, 15(762)

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) (2021)
Klionsky, Daniel J. et al. and Bootman, Martin
Autophagy, 17(1) (pp. 1-382)

Professor Sir Michael Berridge FRS (1938–2020) (2020-04-04)
Bootman, Martin; Galione, Antony and Taylor, Colin
Current Biology, 30(9) (R374-R376)

Fundamentals of Cellular Calcium Signaling: A Primer (2020)
Bootman, Martin D. and Bultynck, Geert
Cold Spring Harbor Perspectives in Biology, 12, Article a038802

Cardiac pathology in neuronal ceroid lipofuscinoses (NCL): More than a mere co-morbidity (2020)
Rietdorf, Katja; Coode, Emily E.; Schulz, Angela; Wibbeler, Eva; Bootman, Martin D. and Ostergaard, John R.
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1866, Article 165643(9)

Examining Cardiomyocyte Dysfunction Using Acute Chemical Induction of an Ageing Phenotype (2020)
Masoud, Said; McDonald, Fraser; Bister, Dirk; Kotecki, Claire; Bootman, Martin D. and Rietdorf, Katja
International Journal of Molecular Sciences, 21, Article 197(1)

T-type calcium channels drive the proliferation of androgen-receptor negative prostate cancer cells (2019-09-15)
Silvestri, Roberto; Pucci, Perla; Venalainen, Erik; Matheou, Chrysanthi; Mather, Rebecca; Chandler, Stephen; Aceto, Romina; Rigas, Sushila; Wang, Yuzhuo; Rietdorf, Katja; Bootman, Martin and Crea, Francesco
The Prostate, 79(13) (pp. 1580-1586)

Constitutive IP3 signaling underlies the sensitivity of B-cell cancers to the Bcl-2/IP3 receptor disruptor BIRD-2 (2019-03-31)
Bittremieux, Mart; La Rovere, Rita M.; Akl, Haidar; Martines, Claudio; Welkenhuyzen, Kirsten; Dubron, Kathia; Baes, Myriam; Janssens, Ann; Vandenberghe, Peter; Laurenti, Luca; Rietdorf, Katja; Morciano, Giampaolo; Pinton, Paolo; Mikoshiba, Katsuhiko; Bootman, Martin D.; Efremov, Dimitar G.; De Smedt, Humbert; Parys, Jan B. and Bultynck, Geert
Cell Death & Differentiation, 26 (pp. 531-547)

Creating a New Cancer Therapeutic Agent by Targeting the Interaction between Bcl-2 and IP (2019)
Distelhorst, Clark W. and Bootman, Martin
Cold Spring Harbor Perspectives in Biology, 11(9)

Deleterious effects of calcium indicators within cells; an inconvenient truth (2018-07)
Bootman, Martin D.; Allman, Sarah; Rietdorf, Katja and Bultynck, Geert
Cell Calcium, 73 (pp. 82-87)

Contractile responses to endothelin-1 are regulated by PKC phosphorylation of cardiac myosin binding protein-C in rat ventricular myocytes (2018-04)
Smyrnias, Ioannis; Goodwin, Normann; Wachten, Dagmar; Skogestad, Jonas; Aronsen, Jan Magnus; Robinson, Emma L.; Demydenko, Kateryna; Segonds-Pichon, Anne; Oxley, David; Sadayappan, Sakthivel; Sipido, Karin; Bootman, Martin D. and Roderick, H. Llewelyn
Journal of Molecular and Cellular Cardiology, 117 (pp. 1-18)

Oncogenic KRAS suppresses store-operated Ca2+ entry and ICRAC through ERK pathway-dependent remodelling of STIM expression in colorectal cancer cell lines (2018-03-14)
Pierro, Cristina; Zhang, Xuexin; Kankeu, Cynthia; Trebak, Mohamed; Bootman, Martin D. and Roderick, H. Llewelyn
Cell Calcium, 72 (pp. 70-80)

The regulation of autophagy by calcium signals: Do we have a consensus? (2018-03)
Bootman, Martin D.; Chehab, Tala; Bultynck, Geert; Parys, Jan B. and Rietdorf, Katja
Cell Calcium, 70 (pp. 32-46)

Calcium phosphate particles stimulate interleukin-1β release from human vascular smooth muscle cells: A role for spleen tyrosine kinase and exosome release (2018-02-28)
Dautova, Yana; Kapustin, Alexander N.; Pappert, Kevin; Epple, Matthias; Okkenhaug, Hanneke; Cook, Simon J.; Shanahan, Catherine M.; Bootman, Martin D. and Proudfoot, Diane
Journal of Molecular and Cellular Cardiology, 115 (pp. 82-93)

Prognostic relevance of a T-type calcium channels gene signature in solid tumours: A correlation ready for clinical validation (2017-08-28)
Fornaro, Lorenzo; Vivaldi, Caterina; Lin, Dong; Xue, Hui; Falcone, Alfredo; Wang, Yuzhuo; Crea, Francesco and Bootman, Martin D.
PLoS ONE, 12, Article e0182818(8)

Basal ryanodine receptor activity suppresses autophagic flux (2017-05-15)
Vervliet, Tim; Pintelon, Isabel; Welkenhuyzen, Kirsten; Bootman, Martin D.; Bannai, Hiroko; Mikoshiba, Katsuhiko; Martinet, Wim; Nadif Kasri, Nael; Parys, Jan B. and Bultynck, Geert
Biochemical Pharmacology, 132 (pp. 133-142)

Second Messengers (2016-08)
Newton, Alexandra C.; Bootman, Martin D. and Scott, John D.
Cold Spring Harbor Perspectives in Biology, 8, Article a005926(8)

Exosomes bind to autotaxin and act as a physiological delivery mechanism to stimulate LPA receptor signalling in cells (2016)
Jethwa, Susanna A.; Leah, Emma J.; Zhang, Qifeng; Bright, Nicholas A.; Oxley, David; Bootman, Martin D.; Rudge, Simon A. and Wakelam, Michael J. O.
Journal of Cell Science, 129(20) (pp. 3948-3957)

Unifying principles of calcium wave propagation — Insights from a three-dimensional model for atrial myocytes (2015-09)
Thul, R.; Rietdorf, K.; Bootman, M. D. and Coombes, S.
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1853(9) (pp. 2131-2143)

Pulmonary vein sleeve cell excitation–contraction-coupling becomes dysynchronized by spontaneous calcium transients (2015)
Rietdorf, Katja; Masoud, Said; McDonald, Fraser; Sanderson, Michael J. and Bootman, Martin D.
Biochemical Society Transactions, 43(3) (pp. 410-416)

Atrial myocytes demonstrate the diversity of cardiac calcium signalling (2015)
Bootman, Martin D. and Rietdorf, Katja
Channels, 9(5) (pp. 219-220)

Fetuin-A and albumin alter cytotoxic effects of calcium phosphate nanoparticles on human vascular smooth muscle cells (2014-05-21)
Dautova, Yana; Kozlova, Diana; Skepper, Jeremy N.; Epple, Matthias; Bootman, Martin D. and Proudfoot, Diane
PLoS ONE, 9, Article e97565(5)

Oncogenic K-Ras suppresses IP3-dependent Ca2+ release through remodelling of IP3Rs isoform composition and ER luminal Ca2+ levels in colorectal cancer cell lines (2014-03-31)
Pierro, Cristina; Cook, Simon J.; Foets, Thomas C. F.; Bootman, Martin D. and Roderick, H. Llewelyn
Journal of Cell Science, 127(7) (pp. 1607-1619)

Spontaneous, pro-arrhythmic calcium signals disrupt electrical pacing in mouse pulmonary vein sleeve cells (2014)
Rietdorf, Katja; Bootman, Martin and Sanderson, Michael J.
PLoS ONE, 9, Article e88649(2)

Fluorescence microscopy (2014)
Sanderson, Michael J.; Smith, Ian; Parker, Ian and Bootman, Martin D.
Cold Spring Harbor Protocols, 2014(10) (pp. 1042-1065)

Alzheimer’s disease-associated peptide Aβ42 mobilizes ER Ca2+ via InsP3R-dependent and -independent mechanisms (2013-11-05)
Jensen, Laura E.; Bultynck, Geert; Luyten, Tomas; Amijee, Hozeefa; Bootman, Martin D. and Roderick, H. Llewelyn
Frontiers in Molecular Neuroscience, 6, Article 36

Loading fluorescent Ca2+ indicators into living cells (2013-02)
Bootman, Martin D.; Rietdorf, Katja; Collins, Tony; Walker, Simon and Sanderson, Michael
Cold Spring Harbor Protocols, 2013, Article pdb.prot072801(2)

Ca2+-sensitive fluorescent dyes and intracellular Ca2+ imaging (2013-02)
Bootman, Martin D.; Rietdorf, Katja; Collins, Tony; Walker, Simon and Sanderson, Michael
Cold Spring Harbor Protocols, 2013, Article pdb.top066050(2)

Converting fluorescence data into Ca2+ concentration (2013)
Bootman, Martin D.; Rietdorf, Katja; Collins, Tony; Walker, Simon and Sanderson, Michael
Cold Spring Harbor Protocols, 2013(2) (pp. 126-129)

Intra-axonal calcium changes after axotomy in wild-type and slow Wallerian degeneration axons (2012-09-07)
Adalbert, R.; Morreale, G.; Paizs, M.; Conforti, L.; Walker, S. A.; Roderick, H. L.; Bootman, Martin; Siklós, L and Coleman, M. P.
Neuroscience, 225C (pp. 44-54)

Calcium signaling (2012-07)
Bootman, Martin
Cold Spring Harbor perspectives in biology, 4(7) (a011171)

Subcellular calcium dynamics in a whole-cell model of an atrial myocyte (2012-02-07)
Thul, Rüdiger; Coombes, Stephen; Roderick, H. Llewelyn and Bootman, Martin D.
Proceedings of the National Academy of Sciences of the United States of America, 109(6) (pp. 2150-5)

Persistence of pro-arrhythmic spatio-temporal calcium patterns in atrial myocytes: a computational study of ping waves (2012)
Thul, Rüdiger; Coombes, Stephen and Bootman, Martin D.
Frontiers in physiology, 3 (p 279)

Calcium signaling in cardiac myocytes (2011-11)
Fearnley, C. J.; Roderick, H. L. and Bootman, M. D.
Cold Spring Harbor perspectives in biology, 3(11) (a004242)

Bcl-2 interaction with the inositol 1,4,5-trisphosphate receptor: role in Ca2+ signaling and disease (2011-09)
Distelhorst, Clark W. and Bootman, Martin D.
Cell Calcium, 50(3) (pp. 234-41)

Non-immortalized human neural stem (NS) cells as a scalable platform for cellular assays (2011-09)
Hook, Lilian; Vives, Joaquim; Fulton, Norma; Leveridge, Mathew; Lingard, Sarah; Bootman, Martin D.; Falk, Anna; Pollard, Steven M.; Allsopp, Timothy E.; Dalma-Weiszhausz, Dennise; Tsukamoto, Ann; Uchida, Nobuko and Gorba, Thorsten
Neurochemistry International, 59(3) (pp. 432-44)

Atrial cardiomyocyte calcium signalling (2011-05)
Bootman, Martin D.; Smyrnias, Ioannis; Thul, Rüdiger; Coombes, Stephen and Roderick, H. Llewelyn
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1813(5) (pp. 922-34)

Melatonin triggers PKA activation in the rodent malaria parasite Plasmodium chabaudi (2011-01)
Gazarini, Marcos L.; Beraldo, Flávio H.; Almeida, Fabiana M.; Bootman, Martin; Da Silva, Aline M. and Garcia, Célia R. S.
Journal of Pineal Research, 50(1) (pp. 64-70)

Comparison of the T-tubule system in adult rat ventricular and atrial myocytes, and its role in excitation-contraction coupling and inotropic stimulation (2010-03)
Smyrnias, Ioannis; Mair, Waltraud; Harzheim, Dagmar; Walker, Simon A.; Roderick, H. Llewelyn and Bootman, Martin D.
Cell Calcium, 47(3) (pp. 210-23)

Exposure to GSM RF fields does not affect calcium homeostasis in human endothelial cells, rat pheocromocytoma cells or rat hippocampal neurons (2010)
O'Connor, Rodney P.; Madison, Steve D.; Leveque, Philippe; Roderick, H. Llewelyn and Bootman, Martin D.
PloS one, 5(7) (e11828)

Elevated InsP3R expression underlies enhanced calcium fluxes and spontaneous extra-systolic calcium release events in hypertrophic cardiac myocytes (2010)
Harzheim, Dagmar; Talasila, Amarnath; Movassagh, Mehregan; Foo, Roger S-Y.; Figg, Nichola; Bootman, Martin D. and Roderick, H. Llewelyn
Channels (Austin), 4(1) (pp. 67-71)

Glucocorticoid-mediated inhibition of Lck modulates the pattern of T cell receptor-induced calcium signals by down-regulating inositol 1,4,5-trisphosphate receptors (2009-11-13)
Harr, Michael W.; Rong, Yiping; Bootman, Martin D.; Roderick, H. Llewelyn and Distelhorst, Clark W.
The Journal of Biological Chemistry, 284(46) (pp. 31860-31871)

The BH4 domain of Bcl-2 inhibits ER calcium release and apoptosis by binding the regulatory and coupling domain of the IP3 receptor (2009-08-25)
Rong, Yi-Ping; Bultynck, Geert; Aromolaran, Ademuyiwa S.; Zhong, Fei; Parys, Jan B.; De Smedt, Humbert; Mignery, Gregory A.; Roderick, H Llewelyn; Bootman, Martin and Distelhorst, Clark W.
Proceedings of the National Academy of Sciences of the United States of America, 106(34) (pp. 14397-14402)

An update on nuclear calcium signalling (2009-07-15)
Bootman, Martin D.; Fearnley, Claire; Smyrnias, Ioannis; MacDonald, Fraser and Roderick, H. Llewelyn
Journal of Cell Science, 122 (pp. 2337-2350)

Increased InsP3Rs in the junctional sarcoplasmic reticulum augment Ca2+ transients and arrhythmias associated with cardiac hypertrophy (2009-07-07)
Harzheim, Dagmar; Movassagh, Mehregan; Foo, Roger S-Y; Ritter, Oliver; Tashfeen, Aslam; Conway, Stuart J.; Bootman, Martin D. and Roderick, H. Llewelyn
Proceedings of the National Academy of Sciences of the United States of America, 106(27) (pp. 11406-11411)

Endothelin-1-stimulated InsP3-induced Ca2+ release is a nexus for hypertrophic signaling in cardiac myocytes (2009-02-27)
Higazi, Daniel R.; Fearnley, Claire J.; Drawnel, Faye M.; Talasila, Amarnath; Corps, Elaine M.; Ritter, Oliver; McDonald, Fraser; Mikoshiba, Katsuhiko; Bootman, Martin D. and Roderick, H. Llewelyn
Molecular cell, 33(4) (pp. 472-482)

Dynamic imaging of calcium and STIM1 in the same cell using wide-field and TIRF microscopy (2008-09)
Walker, Simon; Cunniffe, Nicholas; Bootman, Martin and Roderick, H. Llewelyn
BioTechniques, 45(3) (pp. 347-348)

The cellular concentration of Bcl-2 determines its pro- or anti-apoptotic effect (2008-09)
Hanson, C. Jane; Bootman, Martin D.; Distelhorst, Clark W.; Maraldi, Tullia and Roderick, H. Llewelyn
Cell Calcium, 44(3) (pp. 243-258)

Bcl-2 suppresses Ca2+ release through inositol 1,4,5-trisphosphate receptors and inhibits Ca2+ uptake by mitochondria without affecting ER calcium store content (2008-09)
Hanson, C. Jane; Bootman, Martin D.; Distelhorst, Clark W.; Wojcikiewicz, Richard J. H. and Roderick, H. Llewelyn
Cell Calcium, 44(3) (pp. 324-338)

Calcium phosphate crystals induce cell death in human vascular smooth muscle cells: a potential mechanism in atherosclerotic plaque destabilization (2008-08-29)
Ewence, Alexandra E.; Bootman, Martin D.; Roderick, H. Llewelyn; Skepper, Jeremy N.; McCarthy, Geraldine; Epple, Matthias; Neumann, Markus; Shanahan, Catherine M. and Proudfoot, Diane
Circulation Research, 103(5) (e28-e34)

Emerging roles of inositol 1,4,5-trisphosphate signaling in cardiac myocytes (2008-08)
Kockskämper, Jens; Zima, Aleksey V.; Roderick, H. Llewelyn; Pieske, Burkert; Blatter, Lothar A. and Bootman, Martin D.
Journal of Molecular and Cellular Cardiology, 45(2) (pp. 128-147)

Targeting Bcl-2-IP3 receptor interaction to reverse Bcl-2's inhibition of apoptotic calcium signals (2008-07-25)
Rong, Yi-Ping; Aromolaran, Ademuyiwa S.; Bultynck, Geert; Zhong, Fei; Li, Xiang; McColl, Karen; Matsuyama, Shigemi; Herlitze, Stephan; Roderick, H. Llewelyn; Bootman, Martin D.; Mignery, Gregory A.; Parys, Jan B.; De Smedt, Humbert and Distelhorst, Clark W.
Molecular Cell, 31(2) (pp. 255-265)

Phosphorylation of inositol 1,4,5-trisphosphate receptors by protein kinase B/Akt inhibits Ca2+ release and apoptosis (2008-02-19)
Szado, Tania; Vanderheyden, Veerle; Parys, Jan B.; De Smedt, Humbert; Rietdorf, Katja; Kotelevets, Larissa; Chastre, Eric; Khan, Farid; Landegren, Ulf; Söderberg, Ola; Bootman, Martin D. and Roderick, H. Llewelyn
Proceedings of the National Academy of Sciences of the United States of America, 105(7) (pp. 2427-2432)

Why, where, and when do cardiac myocytes express inositol 1,4,5-trisphosphate receptors? (2008-02)
Bootman, Martin D. and Roderick, H. Llewelyn
American Journal of Physiology. Heart and Circulatory Physiology, 294(2) (H579-H581)

Methacholine and PDGF activate store-operated calcium entry in neuronal precursor cells via distinct calcium entry channels (2008)
Cuddon, Paul; Bootman, Martin D.; Richards, Gillian R.; Smith, Alison J.; Simpson, Peter B. and Roderick, H. Llewelyn
Biological Research, 41(2) (pp. 183-195)

Calcium oscillations (2008)
Thul, Ruediger; Bellamy, Tomas C.; Roderick, H. Llewelyn; Bootman, Martin and Coombes, Stephen
Advances in Experimental Medicine and Biology, 641 (pp. 1-27)

Calcium in the heart: when it's good, it's very very good, but when it's bad, it's horrid (2007-11)
Roderick, H. L.; Higazi, D. R.; Smyrnias, I.; Fearnley, C.; Harzheim, D. and Bootman, M. D.
Biochemical Society transactions, 35(Pt 5) (pp. 957-961)

Temporal changes in atrial EC-coupling during prolonged stimulation with endothelin-1 (2007-10)
Bootman, Martin D.; Harzheim, Dagmar; Smyrnias, Ioannis; Conway, Stuart J. and Roderick, H. Llewelyn
Cell calcium, 42(4-5) (pp. 489-501)

The proapoptotic factors Bax and Bak regulate T Cell proliferation through control of endoplasmic reticulum Ca2+ homeostasis (2007-08)
Jones, Russell G.; Bui, Thi; White, Carl; Madesh, Muniswamy; Krawczyk, Connie M.; Lindsten, Tullia; Hawkins, Brian J.; Kubek, Sara; Frauwirth, Kenneth A.; Wang, Y. Lynn; Conway, Stuart J.; Roderick, H. Roderick; Bootman, Martin D.; Shen, Hao; Foskett, J. Kevin and Thompson, Craig B.
Immunity, 27(2) (pp. 268-280)

Synthesis and biological action of novel 4-position-modified derivatives of D-myo-inositol 1,4,5-trisphosphate (2007-07-20)
Bello, Davide; Aslam, Tashfeen; Bultynck, Geert; Slawin, Alexandra M. Z.; Roderick, H. Llewelyn; Bootman, Martin D. and Conway, Stuart J.
The Journal of Organic Chemistry, 72(15) (pp. 5647-5659)

Pacemaking, arrhythmias, inotropy and hypertrophy: the many possible facets of IP3 signalling in cardiac myocytes (2007-06-15)
Roderick, H. Llewelyn and Bootman, Martin D.
The Journal of Physiology, 581(3) (pp. 883-884)

Defective chemoattractant-induced calcium signalling in S100A9 null neutrophils (2007-02)
McNeill, E.; Conway, S. J.; Roderick, H. L.; Bootman, M. D. and Hogg, N.
Cell Calcium, 41(2) (pp. 107-121)

Interaction between store-operated and arachidonate-activated calcium entry (2007-01)
Holmes, Anthony M; Roderick, H. Llewelyn; McDonald, Fraser and Bootman, Martin D.
Cell calcium, 41(1) (pp. 1-12)

Inositol 1,4,5-trisphosphate supports the arrhythmogenic action of endothelin-1 on ventricular cardiac myocytes (2006-08-15)
Proven, Andrew; Roderick, H. Llewelyn; Conway, Stuart J.; Berridge, Michael J.; Horton, Jeffrey K.; Capper, Stephen J. and Bootman, Martin
Journal of Cell Science, 119(16) (pp. 3363-3375)

Critical role of phospholipase Cϒ1 in the generation of H2O2-evoked [Ca2+]i oscillations in cultured rat cortical astrocytes (2006-05-12)
Hong, Jeong Hee; Moon, Seok Jun; Byun, Hae Mi; Kim, Min Seuk; Jo, Hae; Bae, Yun Soo; Lee, Syng-Ill; Bootman, Martin D.; Roderick, H. Llewelyn; Shin, Dong Min and Seo, Jeong Taeg
Journal of Biological Chemistry, 281(19) (pp. 13057-13067)

New Ca2+ indicator has freedom to express (2006)
Roderick, H. Llewelyn and Bootman, Martin D.
Chemistry & Biology, 13(5) (pp. 463-464)

The JAK3 inhibitor WHI-P154 prevents PDGF-evoked process outgrowth in human neural precursor cells (2006)
Richards, G. R.; Smith, A. J.; Cuddon, P.; Ma, Q. P.; Leveridge, M.; Kerby, J.; Roderick, H. L.; Bootman, M. D. and Simpson, P. B.
Journal of Neurochemistry, 97(1) (pp. 201-210)

The Synthesis of Membrane Permeant Derivatives of myo-Inositol 1,4,5-Trisphosphate (2006)
Conway, Stuart J.; Thuring, Jan W.; Andreu, Sylvain; Kvinlaug, Brynn T.; Roderick, H. Llewelyn; Bootman, Martin and Holmes, Andrew B.
Australian Journal of Chemistry, 59(12) (p 887)

CAPRI and RASAL impose different modes of information processing on Ras due to contrasting temporal filtering of Ca2+ (2005-07-18)
Liu, Qing; Walker, Simon A.; Gao, Dingcheng; Taylor, James A.; Dai, Yan-Feng; Arkell, Rebecca S.; Bootman, Martin D.; Roderick, H. Llewelyn; Cullen, Peter J. and Lockyer, Peter J.
Journal of Cell Biology, 170(2) (pp. 183-190)

XTRPC1-dependent chemotropic guidance of neuronal growth cones (2005-06)
Shim, Sangwoo; Goh, Eyleen L.; Ge, Shaoyu; Sailor, Kurt; Yuan, Joseph P.; Roderick, H. Llewelyn; Bootman, Martin D.; Worley, Paul F.; Song, Hongjun and Ming, Guo-li
Nature Neuroscience, 8(6) (pp. 730-735)

Redoxing calcium from the ER (2005-01-14)
Roderick, H. Llewelyn and Bootman, Martin D.
Cell, 120(1) (pp. 4-5)

The spatial pattern of atrial cardiomyocyte calcium signalling modulates contraction (2004-12-15)
Mackenzie, Lauren; Roderick, H. Llewelyn; Berridge, Michael J.; Conway, Stuart J. and Bootman, Martin D.
Journal of Cell Science, 117(26) (pp. 6327-6337)

Cell signalling: IP3 receptors channel calcium into cell death (2004-11)
Hanson, C. Jane; Bootman, Martin D. and Roderick, H. Llewelyn
Current Biology, 14(21) (R933-R935)

Calmidazolium and arachidonate activate a calcium entry pathway that is distinct from store-operated calcium influx in HeLa cells (2004-08-01)
Peppiatt, Claire M.; Holmes, Anthony M.; Seo, Jeong T.; Bootman, Martin D.; Collins, Tony J.; McDonald, Fraser and Roderick, H. Llewelyn
Biochemical Journal, 381(3) (pp. 929-939)

Bcl-2 functionally interacts with inositol 1,4,5-trisphosphate receptors to regulate calcium release from the ER in response to inositol 1,4,5-trisphosphate (2004-07-19)
Chen, Rui; Valencia, Ignacio; Zhong, Fei; McColl, Karen S.; Roderick, H. Llewelyn; Bootman, Martin D.; Berridge, Michael J.; Conway, Stuart J.; Holmes, Andrew B.; Mignery, Gregory A.; Velez, Patricio and Distelhorst, Clark W.
The Journal of Cell Biology, 166(2) (pp. 193-203)

Regulation of InsP3 receptor activity by neuronal Ca2+-binding proteins (2004-01-28)
Kasri, Nael Nadif; Holmes, Anthony M.; Bultynck, Geert; Parys, Jan B.; Bootman, Martin; Rietdorf, Katja; Missiaen, Ludwig; McDonald, Fraser; De Smedt, Humbert; Conway, Stuart J.; Holmes, Andrew B.; Berridge, Michael J. and Roderick, H. Llewelyn
The EMBO Journal, 23(2) (pp. 312-21)

Calcium influx: is Homer the missing link? (2003-12)
Roderick, H.Llewelyn and Bootman, Martin D.
Current Biology, 13(24) (R976-R978)

Co-incident signalling between μ-opioid and M3 muscarinic receptors at the level of Ca2+ release from intracellular stores: lack of evidence for Ins(1,4,5)P3 receptor sensitization (2003-11-01)
Samways, Damien S. K.; Li, Wen-hong; Conway, Stuart J.; Holmes, Andrew B.; Bootman, Martin D. and Henderson, Graeme
Biochemical Journal, 375(3) (pp. 713-720)

Calcium signalling: dynamics, homeostasis and remodelling (2003-07)
Berridge, Michael J.; Bootman, Martin D. and Roderick, H. Llewelyn
Nature Reviews Molecular Cell Biology, 4(7) (pp. 517-29)

Mitochondria are morphologically heterogeneous within cells (2003-06-15)
Collins, Tony T. and Bootman, Martin D.
Journal of Experimental Biology, 206(12) (pp. 1993-2000)

Calcium-induced calcium release (2003-05-27)
Roderick, H. Llewelyn; Berridge, Michael J. and Bootman, Martin D.
Current Biology, 13(11) (R425)

Local and global spontaneous calcium events regulate neurite outgrowth and onset of GABAergic phenotype during neural precursor differentiation (2003-01-01)
Ciccolini, Francesca; Collins, Tony J.; Sudhoelter, Juliana; Lipp, Peter; Berridge, Michael J. and Bootman, Martin D.
The Journal of Neuroscience, 23(1) (pp. 103-11)

2-Aminoethoxydiphenyl borate (2-APB) antagonises inositol 1,4,5-trisphosphate-induced calcium release, inhibits calcium pumps and has a use-dependent and slowly reversible action on store-operated calcium entry channels (2003)
Peppiatt, Claire M.; Collins, Tony J.; Mackenzie, Lauren; Conway, Stuart J.; Holmes, Andrew B.; Bootman, Martin; Berridge, Michael J.; Seo, Jeong T. and Roderick, H. Llewelyn
Cell Calcium, 34(1) (pp. 97-108)

Calcium signalling: more messengers, more channels, more complexity (2002-08-20)
Bootman, Martin D.; Berridge, Michael J. and Roderick, H. Llewelyn
Current Biology, 12(16) (R563-R565)

Mechanisms underlying the neuronal calcium sensor-1-evoked enhancement of exocytosis in PC12 Cells (2002-08-16)
Koizumi, Schuichi; Rosa, Patrizia; Willars, Gary B.; Challiss, R. A. John; Taverna, Elena; Francolini, Maura; Bootman, Martin D; Inoue, Kazuhide; Roder, John and Jeromin, Andreas
Journal of Biological Chemistry, 277(33) (pp. 30315-30324)

2-Aminoethoxydiphenyl borate (2-APB) is a reliable blocker of store-operated Ca2+ entry but an inconsistent inhibitor of InsP3-induced Ca2+ release (2002-08)
Bootman, Martin D.; Collins, Tony J.; MacKenzie, Lauren; Roderick, H. Llewelyn; Berridge, Michael J. and Peppiatt, Claire M.
The FASEB Journal, 16(10) (pp. 1145-1150)

RyR1 and RyR3 isoforms provide distinct intracellular Ca2+ signals in HEK 293 cells (2002-06-15)
Rossi, Daniela; Simeoni, Ilenia; Micheli, Marcella; Bootman, Martin; Lipp, Peter; Allen, Paul D. and Sorrentino, Vincenzo
Journal of Cell Science, 115(12) (pp. 2497-2504)

Activating calcium release through inositol 1,4,5-trisphosphate receptors without inositol 1,4,5-trisphosphate (2002-05-28)
Bootman, Martin D.; Berridge, Michael J. and Roderick, H. Llewelyn
Proceedings of the National Academy of Sciences of the United States of America, 99(11) (pp. 7320-7322)

Mitochondria are morphologically and functionally heterogeneous within cells (2002-04-02)
Collins, Tony J.; Berridge, Michael J.; Lipp, Peter and Bootman, Martin D.
The EMBO Journal, 21(7) (pp. 1616-1627)

The endoplasmic reticulum is a focal point for co-ordination of cellular activity (2002)
Bootman, Martin; Petersen, Ole H. and Verkhratsky, Alexei
Cell Calcium, 32(5-6) (pp. 231-234)

The role of inositol 1,4,5-trisphosphate receptors in Ca2+ signalling and the generation of arrhythmias in rat atrial myocytes (2002)
Mackenzie, Lauren; Bootman, Martin D.; Laine, Mika; Berridge, Michael J.; Thuring, Jan; Holmes, Andrew; Li, Wen-Hong and Lipp, Peter
The Journal of Physiology, 541(2) (pp. 395-409)

Calcium puffs are generic InsP3-activated elementary calcium signals and are downregulated by prolonged hormonal stimulation to inhibit cellular calcium responses (2001-11-15)
Tovey, Stephen C.; de Smet, Patrick; Lipp, Peter; Thomas, David; Young, Kenneth W.; Missiaen, Ludwig; De Smedt, Humbert; Parys, Jan B.; Berridge, Michael J.; Thuring, Jan; Holmes, Andrew and Bootman, Martin D.
Journal of Cell Science, 114(Pt 22) (pp. 3979-3989)

FENS-1 and DFCP1 are FYVE domain-containing proteins with distinct functions in the endosomal and Golgi compartments (2001-11)
Ridley, S. H.; Ktistakis, N.; Davidson, K.; Anderson, K. E.; Manifava, M.; Ellson, C. D.; Lipp, P.; Bootman, M.; Coadwell, J.; Nazarian, A.; Erdjument-Bromage, H.; Tempst, P.; Cooper, M. A.; Thuring, J. W. J. F.; Lim, Z.-Y.; Holmes, A. B.; Stephens, L. R. and Hawkins, P. T.
Journal of Cell Science, 114(22) (pp. 3991-4000)

Mitochondrial Ca2+ uptake depends on the spatial and temporal profile of cytosolic Ca2+ signals (2001-07-13)
Collins, Tony J.; Lipp, Peter; Berridge, Michael J. and Bootman, Martin D.
Journal of Biological Chemistry, 276(28) (pp. 26411-26420)

The organisation and functions of local Ca2+ signals (2001-06)
Bootman, Martin D.; Lipp, Peter and Berridge, Michael J.
Journal of cell science, 114 (pp. 2213-2222)

Predetermined recruitment of calcium release sites underlies excitation-contraction coupling in rat atrial myocytes (2001-02-01)
Mackenzie, Lauren; Bootman, Martin D.; Berridge, Michael J. and Lipp, Peter
Journal of Physiology, 530(3) (pp. 417-429)

Calcium signalling -an overview (2001-02)
Bootman, Martin D.; Collins, Tony J.; Peppiatt, Claire M.; Prothero, Larissa S.; MacKenzie, Lauren; De Smet, Patrick; Travers, Marianne; Tovey, Stephen C.; Seo, Jeong T.; Berridge, Michael J.; Ciccolini, Francesca and Lipp, Peter
Seminars in cell & developmental biology, 12(1) (pp. 3-10)

Lysophosphatidic acid-induced Ca2+ mobilization requires intracellular sphingosine 1-phosphate production: Potential involvement of endogenous EDG-4 receptors (2000-12-08)
Young, Kenneth W.; Bootman, Martin D.; Channing, Deborah. R.; Lipp, Peter; Maycox, Peter R.; Meakin, Jackie; Challiss, R. A. John and Nahorski, Stefan R.
The Journal of Biological Chemistry, 275(49) (pp. 38532-9)

The versatility and universality of calcium signalling (2000-10)
Berridge, Michael J.; Lipp, Peter and Bootman, Martin D.
Nature Reviews Molecular Cell Biology, 1(1) (pp. 11-21)

A comparison of fluorescent Ca2+ indicator properties and their use in measuring elementary and global Ca2+ signals (2000-10)
Thomas, D.; Tovey, S. C.; Collins, T. J.; Bootman, M. D.; Berridge, M. J. and Lipp, P.
Cell Calcium, 28(4) (pp. 213-223)

Functional InsP3 receptors that may modulate excitation-contraction coupling in the heart (2000-08)
Lipp, Peter; Laine, Mika; Tovey, Stephen C.; Burrell, Kylie M.; Berridge, Michael J.; Li, Wenhong and Bootman, Martin D.
Current biology, 10(15) (pp. 939-942)

Inositol 1,4,5-trisphosphate-induced Ca2+ release is inhibited by mitochondrial depolarization (2000-04-15)
Collins, Tony J.; Lipp, Peter; Berridge, Michael J.; Li, Wenhong and Bootman, Martin D.
Biochemical Journal, 347(2) (pp. 593-600)

Signal transduction. The calcium entry pas de deux (2000-03-03)
Berridge, Michael J.; Lipp, Peter and Bootman, Martin D.
Science, 287(5458) (pp. 1604-1605)

Nuclear calcium signalling (2000-03)
Bootman, M. D.; Thomas, D.; Tovey, S. C.; Berridge, M. J. and Lipp, P.
Cellular and Molecular Life Sciences, 57(3) (pp. 371-378)

Microscopic properties of elementary Ca2+ release sites in non-excitable cells (2000-01-13)
Thomas, David; Lipp, Peter; Tovey, Stephen C.; Berridge, Michael J.; Li, Wenhong; Tsien, Roger Y. and Bootman, Martin D.
Current biology, 10(1) (pp. 8-15)

Calcium-modulating cyclophilin ligand desensitizes hormone-evoked calcium release (2000)
Tovey, Stephen C.; Bootman, Martin D.; Lipp, Peter; Berridge, Michael J. and Bram, Richard J.
Biochemical and Biophysical Research Communications, 276(1) (pp. 97-100)

Ringing changes to the 'bell-shaped curve' (1999-12-02)
Bootman, Martin D. and Lipp, Peter
Current biology, 9(23) (R876-R878)

Regulation of ryanodine receptor opening by lumenal Ca2+ underlies quantal Ca2+ release in PC12 cells (1999-11-19)
Koizumi, Schuichi; Lipp, Peter; Berridge, Michael J. and Bootman, Martin D.
Journal of Biological Chemistry, 274(47) (pp. 33327-33333)

Molecular cloning and immunolocalization of a novel vertebrate trp homologue from Xenopus (1999-06-15)
Bobanović, Laura K.; Laine, Mika; Petersen, Carl C. H.; Bennett, Deborah L.; Berridge, Michael J.; Lipp, Peter; Ripley, Scott J. and Bootman, Martin D.
Biochemical Journal, 340 (pp. 593-599)

Calcium signalling (1999-03-11)
Berridge, Michael; Lipp, Peter and Bootman, Martin
Current Biology, 9(5) (R157-R159)

Elementary [Ca2+]i signals generated by electroporation functionally mimic those evoked by hormonal stimulation (1999-02)
Bobanović, Fedja; Bootman, Martin D.; Berridge, Michael J.; Parkinson, Nicola A. and Lipp, Peter
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 13(2) (pp. 365-376)

Characterization of elementary Ca2+ release signals in NGF-differentiated PC12 cells and hippocampal neurons (1999-01)
Koizumi, Schuichi; Bootman, Martin D.; Bobanović, Laura K.; Schell, Michael J.; Berridge, Michael J. and Lipp, Peter
Neuron, 22(1) (pp. 125-37)

Hormone-evoked elementary Ca2+ signals are not stereotypic, but reflect activation of different size channel clusters and variable recruitment of channels within a cluster (1998-10-16)
Thomas, David; Lipp, Peter; Berridge, Michael J. and Bootman, Martin D.
Journal of Biological Chemistry, 273(42) (pp. 27130-27136)

Calcium - a life and death signal (1998-10-15)
Berridge, Michael J.; Bootman, Martin D. and Lipp, Peter
Nature, 395(6703) (pp. 645-648)

Which Ca2+ channels control cardiac E-C coupling? (1998-04-15)
Lipp, Peter and Bootman, Martin
The Journal of Physiology, 508(2) (p 331)

Ca2+ entry into PC12 cells initiated by ryanodine receptors or inositol 1,4,5-trisphosphate receptors (1998-01-15)
Bennett, Deborah L.; Bootman, Martin D.; Berridge, Michael J. and Cheek, Timothy R.
Biochemical Journal, 329 (pp. 349-357)

Nuclear calcium signalling by individual cytoplasmic calcium puffs (1997-12-01)
Lipp, Peter; Thomas, David; Berridge, Michael J. and Bootman, Martin D.
The EMBO journal, 16, Article PMC1170317(23) (pp. 7166-7173)

Cooking with calcium: the recipes for composing global signals from elementary events (1997-10-31)
Bootman, Martin D.; Berridge, Michael J. and Lipp, Peter
Cell, 91(3) (pp. 367-73)

To quark or to spark, that is the question (1997-07-01)
Lipp, P. and Bootman, M. D.
The Journal of physiology, 502(1) (p 1)

Imaging the hierarchical Ca2+ signalling system in HeLa cells (1997-03-01)
Bootman, Martin; Niggli, Ernst; Berridge, Michael and Lipp, Peter
The Journal of Physiology, 499(2) (pp. 307-314)

Hormone-evoked subcellular Ca2+ signals in HeLa cells (1996-08)
Bootman, Martin
Cell calcium, 20(2) (pp. 97-104)

Subcellular Ca2+ signals underlying waves and graded responses in HeLa cells (1996-07-01)
Bootman, Martin D. and Berridge, Michael J.
Current Biology, 6(7) (pp. 855-865)

Expression and function of ryanodine receptors in nonexcitable cells (1996-03-15)
Bennett, Deborah L.; Cheek, Timothy R.; Berridge, Michael J.; De Smedt, Humbert; Parys, Jan B.; Missiaen, Ludwig and Bootman, Martin D.
Journal of Biological Chemistry, 271(11) (pp. 6356-6362)

Extracellular calcium concentration controls the frequency of intracellular calcium spiking independently of inositol 1,4,5-trisphosphate production in HeLa cells (1996-02-15)
Bootman, M. D.; Young, K. W.; Young, J. M.; Moreton, R. B. and Berridge, M. J.
Biochemical Journal, 314 (pp. 347-354)

The elemental principles of calcium signaling (1995-12-01)
Bootman, Martin D. and Berridge, Michael J.
Cell, 83(5) (pp. 675-678)

Slow kinetics of InsP3-induced Ca2+ release: differences between uni- and bi-directional 45Ca2+ fluxes (1995-08)
Missiaen, L.; Parys, J. B.; De Smedt, H.; Lemaire, F. X.; Sienaert, I.; Bootman, M. D. and Casteels, R.
Cell Calcium, 18(2) (pp. 100-110)

Rat basophilic leukemia cells as model system for inositol 1,4,5-trisphosphate receptor IV, a receptor of the type II family: functional comparison and immunological detection (1995-04)
Parys, J. B.; de Smedt, H.; Missiaen, L.; Bootman, M. D.; Sienaert, I. and Casteels, R.
Cell Calcium, 17(4) (pp. 239-249)

Control of inositol 1,4,5-trisphosphate-induced Ca2+ release by cytosolic Ca2+ (1995-03-01)
Bootman, Martin D.; Missiaen, Ludwig; Parys, Jan B.; De Smedt, Humbert and Casteels, Rik
Biochemical Journal, 306 (pp. 445-451)

Smoothly graded Ca2+ release from inositol 1,4,5-trisphosphate-sensitive Ca2+ stores (1994-10-07)
Bootman, Martin D.; Cheek, Tim R.; Moreton, Roger B.; Bennett, Deborah L. and Berridge, Michael J.
Journal of Biological Chemistry, 269(40) (pp. 24783-24791)

Vasopressin responses in electrically coupled A7r5 cells (1994-10)
Missiaen, Ludwig; Oike, Masahiro; Bootman, Martin D.; De Smedt, Humbert; Parys, Jan B. and Casteels, Rik
Pflügers Archiv, 428(3-4) (pp. 283-287)

Determination of relative amounts of inositol trisphosphate receptor mRNA isoforms by ratio polymerase chain reaction (1994-08-26)
De Smedt, Humbert; Missiaen, Ludwig; Parys, Jan B.; Bootman, Martin D.; Mertens, Luc; Van Den Bosch, Ludo and Casteels, Rik
The Journal of Biological Chemistry, 269(34) (pp. 21691-21698)

Quantal Ca2+ mobilization by ryanodine receptors is due to all-or-none release from functionally discrete intracellular stores (1994-08-01)
Cheek, T. R.; Berridge, M. J.; Moreton, R. B.; Stauderman, K. A.; Murawsky, M. M. and Bootman, M. D.
The Biochemical Journal, 301 (pp. 879-883)

Differences in intracellular calcium signaling after activation of the thrombin receptor by thrombin and agonist peptide in osteoblast-like cells (1994-06-24)
Jenkins, Alison L.; Bootman, Martin D.; Berridge, Michael J. and Stone, Stuart R.
The Journal of Biological Chemistry, 269(25) (pp. 17104-17110)

Questions about quantal Ca2+ release (1994-02-01)
Bootman, Martin
Current Biology, 4(2) (pp. 169-172)

Quantal Ca2+ release from InsP3-sensitive intracellular Ca2+ stores (1994-01)
Bootman, Martin D.
Molecular and Cellular Endocrinology, 98(2) (pp. 157-166)

Quantal Ca2+ release from caffeine-sensitive stores in adrenal chromaffin cells (1993-12-25)
Cheek, Timothy R.; Moreton, Roger B.; Berridge, Michael J.; Stauderman, Kenneth A.; Murawsky, Michael M. and Bootman, Martin D.
Journal of Biological Chemistry, 268(36) (pp. 27076-27083)

Characterization of the receptor responsible for thrombin-induced intracellular calcium responses in osteoblast-like cells (1993-10-05)
Jenkins, Alison L.; Bootman, Martin D.; Taylor, Colin W.; Mackie, Eleanor J. and Stone, Stuart R.
Journal of Biological Chemistry, 268(28) (pp. 21433-21437)

Calcium regulation in tissue-cultured human and bovine lens epithelial cells (1993-09)
Duncan, G.; Webb, S. F.; Dawson, A. P.; Bootman, M. D. and Elliott, A. J.
Investigative Ophthalmology & Visual Science, 34(10) (pp. 2835-2842)

Normal Ca2+ signalling in glutathione-depleted and dithiothreitol-treated HeLa cells (1993-06)
Missiaen, Ludwig; Parys, Jan B.; Bootman, Martin D.; De Smedt, Humbert; Droogmans, Guy and Casteels, Rik
Pflügers Archiv, 423(5-6) (pp. 480-484)

The thiol reagent, thimerosal, evokes Ca2+ spikes in HeLa cells by sensitizing the inositol 1,4,5-trisphosphate receptor (1992-12-15)
Bootman, Martin D.; Taylor, Colin W. and Berridge, Michael J.
Journal of Biological Chemistry, 267(35) (pp. 25113-25119)

All-or-nothing Ca2+ mobilization from the intracellular stores of single histamine-stimulated HeLa cells (1992-05)
Bootman, Martin D.; Berridge, Michael J. and Taylor, Colin W.
Journal of Physiology, 450 (pp. 163-178)

Two sulphonated dye compounds which compete for inositol 1,4, 5-trisphosphate binding to rat liver microsomes: effects on 5'-phosphatase activity (1990-02-14)
Bootman, Martin D.; Pay, Graham F.; Rick, Caroline E. and Tones, Michael A.
Biochemical and biophysical research communications, 166(3) (pp. 1334-1339)

The effect of heparin on the inositol 1,4,5-trisphosphate receptor in rat liver microsomes: dependence on sulphate content and chain length (1989-07-31)
Tones, Michael A.; Bootman, Martin D.; Higgins, Bernard F.; Lane, David A.; Pay, Graham F. and Lindahl, Ulf
FEBS Letters, 252(1-2) (pp. 105-108)

Tissue Specificity: Store-Operated Ca2+ Entry in Cardiac Myocytes (2017)
Bootman, Martin D. and Rietdorf, Katja
In: Groschner, K.; Graier, W. and Romanin, C. eds. Store-Operated Ca²⁺ Entry (SOCE) Pathways. Advances in Experimental Medicine and Biology (pp. 363-387)
ISBN : 978-3-319-57732-6 | Publisher : Springer

Excitation–Contraction Coupling (2012)
Smyrnias, Ioannis; Bootman, Martin and Roderick, H. Llewelyn Roderick
In: Mooren, Frank C. ed. Encyclopedia of Exercise Medicine in Health and Disease (pp. 310-314)
Publisher : Springer

Using calcium imaging as a readout of GPCR activation (2011)
Bootman, Martin and Roderick, H. Llewelyn
In: Willars, Gary B and Challiss, R A John eds. Receptor Signal Transduction Protocols (pp. 277-296)
Publisher : Springer

Calcium signalling and regulation of cell function (2002-01-01)
Bootman, Martin and Lipp, Peter
In: Zheng, Yixian ed. Encyclopedia of Life Sciences
ISBN : 9780470016176 | Publisher : Wiley | Published : Chichester

Control of the Ca2+ release induced by myo-inositol trisphosphate and the implication in signal transduction (1996)
Missiaen, L.; Parys, J. B.; De Smedt, H.; Sienaert, I.; Bootman, M. D. and Casteels, R.
In: Biswas, B. B. and Biswas, Susweta eds. myo-Inositol Phosphates, Phosphoinositides, and Signal Transduction. Subcellular Biochemistry (26) (pp. 59-95)
ISBN : 978-0306-45221-5 | Publisher : Plenum Press | Published : London

Long non-coding RNAs are key players in Prostate cancer tumorigenesis and drug resistance (2020-10)
Pucci, Perla; Crea, Francesco; Alborelli, Ilaria; Quagliata, Luca; Bootman, Martin; Rigas, Sushilaben; Romero, Ignacio and Wang, Yuzhuo
In : 27th Annual PCF Scientific Retreat Virtual Poster Session (20-23 Oct 2020, Virtual)

Broken Hearts in Juvenile Dementia: investigating cardiac myocytes in CLN3 disease (2019)
Coode, Emily; McDonald, Fraser; Bister, Dirk; Bootman, Martin and Rietdorf, Katja
In : Gordon Conference on Lysosomal Diseases (3-8 Mar 2019, Galveston, Texas)

Ultrastructural changes in hearts from CLN3 mice (2019)
Rietdorf, K.; Coode, E.; McDonald, F.; Bister, D.; Cooper, J.D. and Bootman, M.
In : Gordon Conference on Lysosomal Diseases (3-8 Mar 2019, Galveston, Texas)

Broken Hearts in Juvenile Dementia: investigating cardiac myocytes in CLN3 disease (2018-09)
Rietdorf, Katja; Coode, Emily; MacDonald, Fraser; Bister, Dirk and Bootman, Martin
In : International Meeting of the European Calcium Society (9-13 Sep 2018, Hamburg, Germany)

Broken Hearts in Juvenile Dementia: investigating cardiac myocytes in CLN3 disease (2018-09)
Rietdorf, Katja; Coode, Emily; MacDonald, Fraser; Bister, Dirk and Bootman, Martin
In : NCL 2018 (12-16 Sep 2018, London. UK)

Inhibition of N-glycanase1 induces autophagic clearance of protein aggregates (2016-12)
Needs, Sarah; Bootman, Martin; Alonzi, Dominic and Allman, Sarah
In : 2016 Annual meeting of the Society for Glycobiology (19-22 Nov 2016, New Orleans, Louisiana, USA) (pp. 1351-1499)

CRISPR /Cas9 gene editing to study N-glycanase1 deficiency (2016-10-19)
Needs, Sarah; Adan, Abdullahi; Berwick, Daniel; Bootman, Martin and Allman, Sarah
In : 3rd BioProNET Annual Scientific Symposium (19-20 Oct 2016, East Midlands Conference Centre, Nottingham, UK)

How does fat cause heart diseases? Effects of epicardial adipocytes on cardiomyocyte signalling and contractility (2016-09)
Masoud, Said; Bootman, Martin D.; McDonald, Fraser; MacQueen, Hilary and Rietdorf, Katja
In : 14th International Meeting of the European Calcium Society (25-29 Sep 2016, Valladolid, Spain)

Can we use chemical-induction of ageing to develop a model of cardiac ageing? (2016-09)
Masoud, Said; Bootman, Martin D.; McDonald, Fraser and Rietdorf, Katja
In : 14th International Meeting of the European Calcium Society (25-29 Sep 2016, Valladolid, Spain)

Calcium phosphate crystals found in atherosclerotic plaques induce cytotoxic effects via loss of cellular calcium homeostasis. (2016-09)
Sharma, Kumar; Rietdorf, Katja; Proudfoot, Diane; McDonald, Fraser and Bootman, Martin D.
In : 14th International Meeting of the European Calcium Society (25-29 Sep 2016, Valladolid, Spain)

Mibefradil; a T-type calcium channel blocker as a potential anti-cancer agent. (2016-09)
Matheou, Chrysanthi; Chandler, Stephen; Crea, Francesco; Faria, Nuno; Powell, Jonathan; McDonald, Fraser; Rietdorf, Katja and Bootman, Martin D.
In : 14th International Meeting of the European Calcium Society (25-29 Sep 2016, Valladolid, Spain)

The sources and characteristics of calcium signals determine whether autophagy is up- or downregulated. (2016-09)
Chehab, Tala; Rietdorf, Katja; Parys, Jan B.; Bultynck, Geert and Bootman, Martin D.
In : 14th International Meeting of the European Calcium Society (25-29 Sep 2016, Valladolid, Spain)

Inhibition of N-linked Protein Deglycosylation Stimulates Autophagy (2016-07-06)
Needs, Sarah; Alonzi, Dominic; Bootman, Martin D. and Allman, Sarah
In : Frankfurt Conference on Ubiquitin and Autophagy "Quality control in Life Processes" (04-07 Jul 2016, Goethe University Hospital, Frankfurt am Main, Germany)

Effects of Inhibition of N-linked Glycosylation on Cellular Autophagy (2016-03-16)
Needs, Sarah; Alonzi, Dominic; Bootman, Martin and Allman, Sarah
In : Evolution brings Ca2+ and ATP together to control life and death (16-17 Mar 2016, Kavli Royal Society Centre, Chicheley Hall, Newport Pagnell)

Chemically inducing ageing in neonatal rat ventricular myocytes (2016-03)
Masoud, Said; Bootman, Martin; McDonald, Fraser and Rietdorf, Katja
In : Evolution brings Ca2+ and ATP together to control life and death (16-17 Mar 2016, Kavli Royal Society Centre, Chicheley Hall, Newport Pagnell)

How cells outside the heart can affect the heart beat: The role of pulmonary vein sleeve cells for the development of atrial fibrillation (2016-03)
Rietdorf, Katja; Masoud, Said; McDonald, Fraser and Bootman, Martin
In : Evolution brings Ca2+ and ATP together to control life and death (16-17 Mar 2016, Kavli Royal Society Centre, Chicheley Hall, Newport Pagnell)

Calcification stimulates inflammatory signalling pathways in human vascular smooth muscle cells (2016-01)
Proudfoot, D.; Dautova, Y.; Kozlova, D.; Epple, M. and Bootman, M. D.
In : Atherosclerosis meeting (2015) (e9-e10)

Intracellular calcium: a dual role in autophagy (2016)
Chehab, Tala; Rietdorf, Katja; Parys, Jan B.; Bultynck, Geert and Bootman, Martin
In : Evolution brings Ca2+ and ATP together to control life and death (16-17 Mar 2016, Chichley Hall, Newport Pagnell)

Calcium phosphate crystals observed during atherosclerosis have a cytotoxic effect that results in loss of calcium homeostasis (2016)
Sharma, Kumar; Rietdorf, Katja; Proudfoot, Diane; McDonald, Fraser and Bootman, Martin
In : Evolution brings Ca2+ and ATP together to control life and death (16-17 Mar 2016, Kavli Royal Society Centre, Chicheley Hall, Newport Pagnell)

How does fat cause heart diseases? Effects of epicardial adipocytes on cardiomyocyte signalling and contractility (2015)
Rietdorf, Katja; MacQueen, Hilary and Bootman, Martin
In : Physiology 2015 (6-8 Jul 2015, Cardiff)

Ageing-induced ultrastructural changes of mitochondria of pulmonary vein sleeve cells (2015)
Masoud, Said; McDonald, Fraser; Bootman, Martin and Rietdorf, Katja
In : Physiology 2015 (6-8 Jul 2015, Cardiff)

Inhibition of calcium release from InsP3Rs triggers autophagy (2015)
Chehab, Tala; Rietdorf, Katja; Parys, Jan; Bultynck, Geert and Bootman, Martin
In : Physiology 2015 (6-8 Jul 2015, Cardiff)

Effect of calcium-phosphate crystals on intracellular calcium homeostasis and viability of smooth muscle cell (2015)
Sharma, G.; Rietdorf, K.; Proudfoot, D.; McDonald, F. and Bootman, M.
In : Physiology 2015 (6-8 Jul 2015, Cardiff, UK)

Intracellular calcium has a dual role in the regulation of autophagy (2015)
Chehab, Tala; Rietdorf, Katja; Parys, Jan B.; Bultynck, Geert and Bootman, Martin
In : 6th ECS Workshop: Calcium and Cell Fate (21-24 Jun 2015, Seillac, France)

How cells outside the heart can affect the heart beat: The role of pulmonary vein sleeve cells for the development of atrial fibrillation (2015)
Rietdorf, Katja; Masoud, Said; McDonald, Fraser and Bootman, Martin
In : Gordon Conference on Calcium Signalling (7-12 Jun 2015, Newry, Maine, USA)

Spontaneous Ca2+ signalling and ultrastructural changes in pulmonary vein sleeve cells during ageing – risk factors for atrial fibrillation? (2014-10-09)
Masoud, Said; Bootman, Martin D.; McDonald, Fraser and Rietdorf, Katja
In : Calcium Signalling: The Next Generation (9-10 Oct 2014, London, UK)

Inhibition of InsP3 receptor signalling induces autophagy (2014-10-09)
Chehab, Tala; Rietdorf, Katja; Parys, Jan B.; Bultynck, Geert and Bootman, Martin D.
In : Calcium Signalling: The Next Generation (9-10 Oct 2014, London, UK)

Novel improved Ca2+ indicator dyes on the market-a comparative study of novel Ca2+ indicators with fluo-4 (2014-10-09)
Rietdorf, Katja; Chehab, Tala; Allman, Sarah and Bootman, Martin D.
In : Calcium Signalling: The Next Generation (9-10 Oct 2014, London, UK)

A comparative study into the ultrastructure changes of atrial myocytes, pulmonary vein sleeve cells and ventricular myocytes during ageing (2014-10-09)
Masoud, Said R.; McDonald, Fraser; Bootman, Martin D. and Rietdorf, Katja
In : Calcium Signalling: The Next Generation (9-10 Oct 2014, London, UK)

Spontaneous Ca2+ signalling and ultrastructural changes in pulmonary vein sleeve cells during ageing – risk factors for atrial fibrillation? (2014-09)
Rietdorf, Katja; Masoud, Said; McDonald, Fraser and Bootman, Martin
In : 13th International Meeting of the European Calcium Society (13-17 Sep 2014, Aixe-en-Provence, France)

Spontaneous Ca2+ signalling in pulmonary vein sleeve cells increases during ageing (2014-06)
Masoud, Said; Bootman, Martin and Rietdorf, Katja
In : Physiology 2014 (30 Jun - 02 Jul 2014, London)

Inhibition of InsP3 receptor signalling induces autophagy (2014)
Chehab, Tala; Rietdorf, Katja; Parys, Jan; Bultynck, Geert and Bootman, Martin
In : 13th International Meeting of the European Calcium Society (13-17 Sep 2014, Aix-en-Provence, France)

In vitro assessment of alveolar macrophage responses to inhaled particulate medicines (2014)
Hutter, V.; Murnane, D.; Rietdorf, K.; Fowler, D.; Walton, C. and Bootman, M.
In : Drug Delivery to the Lungs (DDL25) (10-12 Dec 2014, Edinburgh)