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Dr Nick Chatterton

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Professional biography

I graduated from Cambridge University with an MA in Natural Sciences, this was then followed by an MSc in Chemistry at Imperial College and a PhD in Organometallic Chemistry from Kings College London in 2003. Since then I have further done research in inorganic chemistry in France (CEA, Grenoble), been a teaching fellow at Sheffield University and prior to joining the OU in June 2015 was a Senior Lecturer in Chemistry and Course Leader in Pharmaceutical Sciences at London Metropolitan University for 8 years. I am also an associate editor for the journal RSC Advances. 

Research interests

My research interests primarily involve exploiting electrohydrodynamic techniques (electrospinning and electrospraying) to generate nanomaterials. Our research in this area predominantly focuses on using these techniques to fabricate novel drug delivery systems. The materials generated generally increase the solubility of poorly soluble drug molecules thereby increasing their bioavailability. In addition we have fabricated materials that can tuned to give either sustained or pulsatile release of drug cargo. We are also interested in luminescent solids with unusual optical properties produced via similar techniques to generate highly-tuned materials that act as sensitive sensors of gas molecules.

Teaching interests

I have over 10 years experience of face-to-face teaching (lectures, tutorials etc) at UK universities and joined the OU to gain experience in developing and utlizing distance learning approaches to teach HE level chemistry. Currently I am involved in writing material for S111, S315 and SS002. In addition I am a member of the presenting module team for S315 providing support for various inorganic chemistry sections and an online interactive practical on drug-drug interactions.  

External collaborations

Dr Gareth Williams (UCL, School of Pharmacy)

Dr Samir Nuseibeh and Dr Kenneth White (London Metropolitan University, School of Human Sciences)

Dr Gemma Shearman (Kingston University, Pharmacy and Chemistry)

Prof Deng-Guang Yu (Shanghai University of Science and Technology)

Research Activity

Externally funded projects

Evaluating immobilised Enzymes on Chitosan for Upcycling Protein Wastes

RoleStart dateEnd dateFunding source
Co-investigator04/Jul/201626/Aug/2016IB Carb Network
This is a pilot research project for an undergraduate student. The project builds on my previous research functionalizing the carbohydrates starch and chitosan to produce new functional materials. This project will support proteases on chitosan to produce recyclable and stable catalysts for the hydrolysis of protein wastes to more valuable hydrolysates. WRAP has estimated waste in the food and drinks supply chain (WRAP 01 312 PAD102-308) reporting that ‘about 2.25 million tonnes of material are rendered each year to produce around 500,000 tonnes of protein meal.’ This example represents an important biorefinery resource for valuable proteins, peptides and amino acids. Protein containing wastes arise from several food industries and the focus here will be from cheese production (whey protein), connective tissue (the protein collagen which yields gelatin), and eggs (ovalbumin). The hydrolysates from waste proteins often display improved antioxidant properties compared to the protein and this will be also studied.

Publications

5-Fluorouracil loaded Eudragit fibers prepared by electrospinning (2015-11-30)
Illangakoon, U. Eranka; Yu, Deng-Guang; Ahmad, Bilal S.; Chatterton, Nicholas P. and Williams, Gareth R.
International Journal of Pharmaceutics, 495(2) (pp. 895-902)
Structural lipid nanoparticles self-assembled from electrospun core–shell polymeric nanocomposites (2015)
Yu, Deng-Guang; White, Kenneth; Chatterton, Nicholas; Li, Ying; Li, Lingling and Wang, Xia
RSC Advances, 5(13) (pp. 9462-9466)
Structure-tunable Janus fibers fabricated using spinnerets with varying port angles (2015)
Chen, Gaoyun; Xu, Ying; Yu, Deng-Guang; Zhang, Dao-Fang; Chatterton, Nicholas P. and White, Kenneth N.
Chemical Communications, 51(22) (pp. 4623-4626)
Fast dissolving paracetamol/caffeine nanofibers prepared by electrospinning (2014-12-30)
Illangakoon, U. Eranka; Gill, Hardyal; Shearman, Gemma C.; Parhizkar, Maryam; Mahalingam, Sunthar; Chatterton, Nicholas P. and Williams, Gareth R.
International Journal of Pharmaceutics, 477(1-2) (pp. 369-379)
Pulsatile drug release from electrospun poly(ethylene oxide)–sodium alginate blend nanofibres (2014)
Kaassis, Abdessamad Y. A.; Young, Neil; Sano, Naoko; Merchant, Hamid A.; Yu, Deng-Guang; Chatterton, Nicholas P. and Williams, Gareth R.
Journal of Materials Chemistry B, 2(10) (pp. 1400-1407)
Sensitized terbium(III) macrocyclic-phthalimide complexes as luminescent pH switches (2013-10-21)
Chen, Gaoyun; Wardle, Nicholas J.; Sarris, Jason; Chatterton, Nicholas P. and Bligh, S. W. Annie
Dalton Transactions, 42(39) (pp. 14115-14124)
Polyacrylonitrile nanofibers coated with silver nanoparticles using a modified coaxial electrospinning process (2012-11-12)
Yu, Deng-Guang; Zhou, Jie; Chatterton, Nicholas P.; Li, Ying; Huang, Jing and Wang, Xia
International Journal of Nanomedicine, 2012(7) (pp. 5725-5732)
A chemically unlocked binary molecular switch (2012-09-18)
Chen, Gaoyun; Sarris, Jason L.; Wardle, Nicholas J.; Bligh, S. W. Annie and Chatterton, Nicholas P.
Chemical Communications, 48(72) (pp. 9026-9028)
Coaxial electrospinning with Triton X-100 solutions as sheath fluids for preparing PAN nanofibers (2012-05)
Yu, Deng-Guang; Chatterton, Nicholas P.; Yang, Jun-He; Wang, Xia and Liao, Yao-Zu
Macromolecular Materials and Engineering, 297(5) (pp. 395-401)
Self-assembled liposomes from amphiphilic electrospun nanofibers (2011-09-21)
Yu, Deng-Guang; Branford-White, Christopher; Williams, Gareth R.; Bligh, S. W. Annie; White, Kenneth; Zhu, Li-Min and Chatterton, Nicholas P.
Soft Matter, 7(18) (pp. 8239-8247)
A modified coaxial electrospinning for preparing fibers from a high concentration polymer solution (2011-08)
Yu, D. G.; Branford-White, C.; White, K.; Chatterton, N. P.; Zhu, L. M.; Huang, L. Y. and Wang, B.
Express Polymer Letters, 5(8) (pp. 732-741)
Helium/oxygen atmospheric pressure plasma jet treatment for hydrophilicity improvement of grey cotton knitted fabric (2011-06-01)
Tian, Liqiang; Nie, Huali; Chatterton, Nicholas P.; Branford-White, Christopher J.; Qiu, Yiping and Zhu, Limin
Applied Surface Science, 257(16) (pp. 7113-7118)
Improving Polymer Nanofiber Quality Using a Modified Co-axial Electrospinning Process (2011-05-18)
Yu, Deng-Guang; Branford-White, Christopher; Bligh, S. W. Annie; White, Kenneth; Chatterton, Nicholas P. and Zhu, Li-Min
Macromolecular Rapid Communications, 32(9-10) (pp. 744-750)
Electrospun diclofenac sodium loaded Eudragit® L 100-55 nanofibers for colon-targeted drug delivery (2011-04-15)
Shen, Xiaxia; Yu, Dengguang; Zhu, Limin; Branford-White, Christopher; White, Kenneth and Chatterton, Nicholas P.
International Journal of Pharmaceutics, 408(1-2) (pp. 200-207)
Preparation of core-shell PAN nanofibers encapsulated α-tocopherol acetate and ascorbic acid 2-phosphate for photoprotection (2011-01-01)
Wu, Xiao-Mei; Branford-White, Christopher J.; Yu, Deng-Guang; Chatterton, Nicholas P. and Zhu, Li-Min
Colloids and Surfaces B: Biointerfaces, 82(1) (pp. 247-252)
Electrospinning of concentrated polymer solutions (2010-12-28)
Yu, Deng-Guang; Branford-White, Christopher J.; Chatterton, Nicholas P.; White, Kenneth; Zhu, Li-Min; Shen, Xia-Xia and Nie, Wei
Macromolecules, 43(24) (pp. 10743-10746)
Ester prodrug-loaded electrospun cellulose acetate fiber mats as transdermal drug delivery systems (2010-08)
Wu, Xiao-mei; Branford-White, Christopher J.; Zhu, Li-min; Chatterton, Nicholas P. and Yu, Deng-guang
Journal of Materials Science: Materials in Medicine, 21(8) (pp. 2403-2411)
Nature of the bonding in metal-silane σ-complexes (2009-02-16)
McGrady, G. Sean; Sirsch, Peter; Chatterton, Nicholas P.; Ostermann, Andreas; Gatti, Carlo; Altmannshofer, Sandra; Herz, Verena; Eickerling, Georg and Scherer, Wolfgang
Inorganic Chemistry, 48(4) (pp. 1588-1598)
Relating structural and thermodynamic effects of the Pb(II) lone pair: a new picolinate ligand designed to accommodate the Pb(II) lone pair leads to high stability and selectivity (2007-04-30)
Pellissier, Aymeric; Bretonnière, Yann; Chatterton, Nicholas; Pécaut, Jacques; Delangle, Pascale and Mazzanti, Marinella
Inorganic Chemistry, 46(9) (pp. 3714-3725)
Elucidation of the bonding in Mn(η2-SiH) complexes by charge density analysis and T1 NMR measurements: asymmetric oxidative addition and anomeric effects at silicon (2006-07-28)
Scherer, Wolfgang; Eickerling, Georg; Tafipolsky, Maxim; McGrady, G. Sean; Sirsch, Peter and Chatterton, Nicholas P.
Chemical Communications(28) (pp. 2986-2988)
An efficient design for the rigid assembly of four bidentate chromophores in water-stable highly luminescent lanthanide complexes (2005-11-25)
Chatterton, Nicholas; Bretonnière, Yann; Pécaut, Jacques and Mazzanti, Marinella
Angewandte Chemie International Edition, 44(46) (pp. 7595-7598)
The effect of pyridinecarboxylate chelating groups on the stability and electronic relaxation of gadolinium complexes (2005-03-21)
Chatterton, Nicholas; Gateau, Christelle; Mazzanti, Marinella; Pécaut, Jacques; Borel, Alain; Helm, Lothar and Merbach, André
Dalton Transactions(6) (pp. 1129-1135)
Structure of the elusive hydrido(methylcyclopentadienyl)dicarbonylmanganate(I) anion, [(η5-C5H4Me)Mn(CO)2H]-, as determined by single-crystal X-ray diffraction (2004-03-01)
Chatterton, Nicholas P.; Guilera, Gemma and McGrady, G. Sean
Organometallics, 23(5) (pp. 1165-1167)
View from the bridge: a pseudo-Jahn-Teller approach to transition metal hydrosilane complexes (2004)
Paterson, Martin J.; Chatterton, Nicholas P. and McGrady, G. Sean
New Journal of Chemistry, 28(12) (pp. 1434-1436)
Influence of the Counteranion on the Formation of Polymeric Networks by Metal Complexes of Hexamethylenebis(acetamide) (2001)
Chatterton, Nicholas P.; Goodgame, David M. L.; Grachvogel, David A.; Hussain, Izhar; White, Andrew J. P. and Williams, David J.
Inorganic Chemistry, 40(2) (pp. 312-317)
Synthesis, molecular structure and palladium(II) and platinum(II) complex chemistry of 3-(ferrocen-1-yl)-1-(pyridin-2-yl)pyrazole (1996-11-07)
Less, Robert J.; Wicks, Joseph L. M.; Chatterton, Nicholas P.; Dewey, Michael J.; Cromhout, Natalie L.; Halcrow, Malcolm A. and Davies, John E.
Journal of the Chemical Society, Dalton Transactions(21) (pp. 4055-4061)

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