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Miss Nayab Fatima

Profile summary

  • Research Student
  • Research Student
  • Faculty of Science, Technology, Engineering & Mathematics
  • School of Life, Health & Chemical Sciences
  • nayab.fatima

Professional biography

Graduated with Bsc Honours in Biomedical Science and MSc in Biomaterials and Tissue Engineering. Currently working as Ph.D. researcher to cure Brain degenerative Dieeases by using nanotechnology and gene therapy at Open University that is supervised by Prof. David Male.

Research interests

Interested in developing Gold nanoparticles to be used as a nanocarrier for drug delivery of oligonucleotides to work as gene therapeutics for Brain diseases such as Alzheimers, brain cancer, stroke & more.

It has been successfully shown that gold nanocarriers efficiently cross brain endothelium in vitro and enter the CNS in vivo. Therefore, now my further work will involve optimizing the attachment of oligonucleotide cargo molecules to the gold nanocarriers.

The experimental approach will be to use a thiol attached DNA oligonucleotide that could cross the brain endothelial cells as a covalently-bonded cargo on gold glyconanoparticles.

Oligos are promising for Brain diseases because for example siRNA has been proposed for therapeutic uses as they can silence potentially any gene in the body and thus be useful to treat undruggable brain diseases. 

Impact and engagement

Attended conferences:

- Blood Brain Barrier Symposium King College London (2016)

- Annual UK & Ireland Blood Brain Barrier Symposiums in Dublin  (2016)

External collaborations

As Gold Nanoparticles are purchased from Midatech therefore, I closely interact with Midatech Pharma plc for my project and attend annual meetings.

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