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Miss Nayab Fatima

Profile summary

  • Research Student
  • Research Student
  • Faculty of Science, Technology, Engineering & Mathematics
  • School of Life, Health & Chemical Sciences
  • nayab.fatima

Professional biography

Graduated with Bsc Honours in Biomedical Science and MSc in Biomaterials and Tissue Engineering. Currently working as Ph.D. researcher to cure Brain degenerative Diseases by using nanotechnology and gene therapy at Open University, supervised by Prof. David Male.

Research interests

Interested in developing Gold nanoparticles to be used as a nanocarrier for drug delivery of oligonucleotides to work as gene therapeutics for Brain diseases such as Alzheimers, brain cancer, stroke & more.

Drug delivery to the central nervous system is challenging due to the inability of many drugs to cross the blood-brain barrier. One approach to overcome this problem is the use of gold nanoparticles as a delivery system. They exhibit relatively low cytotoxicity and can enter cells by both active and passive uptake mechanisms. It has been successfully shown that gold nanocarriers efficiently cross brain endothelium in vitro and enter the CNS in vivo. Therefore, my further work involves optimizing these ~ 2nm by attaching of oligonucleotide as a therapy cargo molecule onto the gold nanocarriers.

The experimental approach uses thiolated attached DNA oligonucleotide that have potential to cross the brain endothelial cells as a covalently-bonded cargo on gold glyconanoparticles. Oligos are promising for Brain diseases because for example siRNA has been proposed for therapeutic uses as they can delete or silence potentially any gene in the body and thus be useful to treat undruggable brain diseases. 

Teaching interests

MOOC facilitator for HISTOLOGY

specialize in Electron Microscopy, Gels, PCR's, Immunoassays, cell culture, HPLC/FPLC, microCTscan, electrospinning.

Impact and engagement

Attended conferences:

-IBBS and American associate society of pharmaceutical conference for novel approaches to target BBB in Washington DC.

- Blood Brain Barrier Symposium King College London (2016)

- Annual UK & Ireland Blood Brain Barrier Symposiums in Dublin  (2016), portsmouth (2017), Oxford (2018) and Milton Keynes (2019).

External collaborations

As Gold Nanoparticles are purchased from Midatech therefore, I closely interact with Midatech Pharma plc for my project and attend annual meetings.

Koc University in Istanbul 

Midatech pharma -  Bilbao and Spain

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