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Professor Mike G Stewart

Professional biography

Prof. Mike Stewart  is a Professor of Neuroscience in the Department of Life, Health and Chemical  Sciences at the Open University. His group's recent research activities have been concerned with  neurodegenerative changes in the brain in ageing,  and in conditions such as Alzheimer's Disease.

Mike  is involved with a number  of external bodies, both nationally and internationally. He is a member of the EDAB (European Dana Alliance) and was  a member of FENS  (Federation of European Neuroscience Societies) executive  committee from 2010-2015 and  treasurer from 2012-2015. He has been a reviewer for biomedical research funding bodies in  several  countries, including France, Germany, Netherlands, Italy, Portugal, Poland,  Romania, Australia and Hong Kong.  During his career he has given lectures on his research and participated in conferences in  over 20 countries world wide.

In the UK Mike  has reviewed grants for a number of Research Councils, and the Wellcome trust; he was a member of the Motor Neurone Disease Research Association committee from 2010-2015, and chaired the committee from 2012-2015.

He has also led external medical education  programmes doing Pro Bono work in Bangladesh in Dhaka,(2001-2006)  based at BIRDEM (Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders) where he and his colleague Prof Janet Grant developed a distance learning course in Diabetology, which has been taken by over 1000 medical staff.
 
In Ethiopia he and Prof Grant also carried out Pro Bono work from 2007-2013 training  lecturers in a new medical school, St Paul's Hospital Millennium Medical College in Addis Ababa.
 
His current research interest involves investigations of the morphological basis of synaptic plasticity  in neural circuits in the mammalian brain. State of the art technologies are used in order to examine changes that occur at hippocampal synapses following  learning paradigms, and in neurodegeneratve conditions.  This research involves  analysis of synaptic changes and of dendritic spine populations,  as well as quantification of immediate early gene expression in order to determine the precise localisation of synaptic change in the hippocampus following learning,  and in ageing and neurodegenerative conditions.

He held major grants from the EU FP6 programme PROMEMORIA  which involves 14 other research groups and more recently an EU FP7 award,  value 3.9 million Euros MEMSTICK, with 6 partner laboratories. Mike also has held a number of  BBSRC grants, most recently an award to develop novel methods of 3D reconstrcution of neural circuitry

Research interests

My main research interests are centred in Neuroscience - Plasticity of the vertebrate central nervous system (CNS), and the effects of ageing and neurodegeneration on the CNS.  
To date over 180 papers and reviews have been published or are in press, together with 200 abstracts from conference papers.   In addition I have edited five major texts, ANIMAL PHYSIOLOGY (Hodder & Stoughton) (1991); QUANTITATIVE METHODS IN NEUROANATOMY (Wiley) (1992); GROWING AND RESPONDING, Open University Press (1997), MAINTAINING THE WHOLE, Open University Press (1997). DIABETES MELLITUS, Diabetic Association of Bangladesh (2006)
At the Open University, my research concerns  synaptic and neural plasticity.  I have been particularly concerned with investigation of problems involving cellular neurobiology especially neurodegeneration and Alzheimers disease (see publication lists for further details).
I have also been involved in an industrial collaboration with Glaxo-Wellcome and NIMR (MRC- Mill Hill) which has arisen as a result of an MRC foresight link award (£660,000; OU share £330,000). This project involved investigations of the cellular and molecular basis of Alzheimer's disease, using transgenic mice in which a high risk factor for Alzheimer's disease (a human allele of a gene called apolipoprotein E -apoE) has been added (knocked-in) to mice lacking the normal apoE gene. More recently I was awarded a BBSRC Neurone grant (£440,000) as lead investigator with collaborators from UCL and NIMR (MRC), followed by an IAAB award from BBSRC with Collaborators at UCL. Additionally, my research has been supported internally via the Open University Research committee, and externally via grants from the Nuffield foundation, N.I.H. (USA), NATO and EC. British Council, Wellcome Trust and Royal Society exchange grants have also been provided to support collaborative projects with laboratories in Germany, Hungary, Poland and the FSSU.
My most recent awards include a £650K BBSRC grant with Prof Karl Kiese of Kings College London (2012-16) ,  and EU FPVI grants (2005) (value €9.5 million) shared with 12 partner EU laboratories and an FP7 Grant (MEMSTICK)  (value €3.9 million) . This research on neurodegeneration involves study of the morphological effect of N-cell adhesion molecule (N-CAM) mimetics on structure of the hippocampus and prefrontal cortex of rats and mice, and its ability to alleviate cognitive deficits including those induced by B-amyloid which is prevalent in Alzheimer's disease.
 
RECENT PUBLICATIONS
Tigaret, C. M. Thalhammer, A. Rast, G. F.. Specht, C.G Auberson, Y. P. Stewart M.G., Schoepfer, R. (2006) Subunit dependencies of NMDA receptor-induced AMPA receptor internalization. Molecular Pharmacology 69: 1251-1259

Stewart M.G.  Banks, D. (2006) Enhancement of long-term memory retention by Colostrinin in one-day-old chicks trained on a weak passive avoidance learning paradigm. Neurobiol of Learning & Memory 86 66–71

Donohue H.S., Gabbott P.L.A., Davies H.A., Rodriguez J.J., Cordero M.I.,. Sandi C, Medvedev N.I, Popov V.I.,, Colyer F.M., Peddie C.J., Stewart M.G. (2006). Chronic restraint stress induces changes in synapse morphology in stratum lacunosum-moleculare CA1 rat hippocampus: a stereological and three-dimensional ultrastructural study. Neuroscience 140, 597-606

 Lauver, A., Yuan, L-L, Jeromin, A., Stewart M.G., Davies H.A Rodriguez J.J., Pfaffinger. P.,  (2006) Manipulating Kv4.2 Expression Identifies a Specific Component of Hippocampal Pyramidal Neuron A Current that Depends Upon Kv4.2 Expression" J. Neurochem 99(4):1207-23

Popov,VI, Medvedev, NI.,  Patrushev, I.  IIgnat’ev, DA,  Morenkov,ED., Stewart, MG. (2007). Reversible reduction in dendritic spines in CA1 of rat and ground squirrel subjected to hypothermia-normothermia in vivo: a 3-dimensional electron microscope study Neurosci 149. 549–560

 Rodríguez, JJ,  Davies, HA,   Errington, M.L.,  Verkhratsky, A.,  Bliss, TVP, Stewart, M.G. (2008)  Arg3.1/arc expression in hippocampal dentate gyrus astrocytes: ultrastructural evidence and co-localization with glial fibrillary acidic protein. J. Cell., Molec. Medicine 12, (2), 671-678

 Popov,VI, Medvedev, NI.,  Kraev, I., Gabbott. P.L. Davies H.A., Lynch, M.A., Cowley, T., Berezin, V., Bock, E.,  Stewart, MG. (2008) A cell adhesion molecule mimetic, FGL-peptide, induces alterations in synapse and dendritic spine structure in the dentate gyrus of aged rats: a three-dimensional ultrastructural study Europ.J.Neurosci 27,. 301–314

Medvdev, N.I., Rodríguez, JJ, Popov,VI, Davies H.A., Tigaret, C.M. Schoepfer, R. Stewart M.G. (2008)  The GluR2 subunit controls psd complexity and spine shape in the dentate gyrus Europ.J.Neurosci 27: 315–325,

Stewart, M.G., Popov,VI, Medvedev, NI., Gabbott. P.L., Corbett, N., Kraev, I., Davies H.A (2008) Dendritic spine and synapse morphological alterations induced by a neural cell adhesion molecule (NCAM) mimetic. Neurochem. Research DOI 10.1007/s11064-008-9607-y

Peddie, C., Davies, H.A., Colyer F.M; Stewart,  M.G., Rodriguez, J. J. (2008) Colocalisation of serotonin 2A receptors with the glutamate receptor subunits NR1 and GluR2 in the dentate gyrus: anultrastructural study of a modulatory role.  Experimental Neurology 211(2): 561-573.

 Peddie, C., Davies, H.A., Colyer F.M; Stewart,  M.G., Rodriguez, J. J.  (2008) Dendritic colocalisation of serotonin1B receptors and the glutamate NMDA receptor subunit NR1 within the hippocampal dentate gyrus: an ultrastructural study. Journal of Chemical Neuroanatomy 36(1): 17-26.

Stewart M.G. (2008) Colostrinin™- a naturally-occurring compound derived from mammalian colostrum with efficacy in treatment of neurodegenerative diseases, including Alzheimer’s. Expert Opinion on Pharmacotherapy 9 (14):2553-9.

Popov V. Stewart M.G. (2009)  Complexity of Contacts Between Synaptic Boutons and Dendritic Spines in Adult Mammalian Hippocampus: Three-Dimensional Reconstructions from Serial Ultrathin Sections in vivo" Synapse 63: 369–377

Dalllarac, G., Doyere, CV., Davies H.A., Rodriguez-Arellano, JJ, Stewart M.G. (2009)  NMDA-independent changes in expression of PSA-NCAM after induction of LTP and LTD in the rat dentate gyrus in vivo Neuron Glia Biology, 4(3):169-78.

 Kraev, I.V.,  Godukhin,O.V., Patrushev, I.V., Davies, H.A., Popov, V.I,  Stewart.M.G. (2009)  Partial kindling induces neurogenesis, activates astrocytes and alters synaptic morphology in the dentate gyrus of freely moving adult rats.  Neuroscience 162(2):254-67

Popov, V.I, Kraev, I.V., Banks, D., Morenkov. ED, Davies, H.A., Stewart.M.G.  Fesenko, EE.   (2009) Three- dimensional ultrastructural and immunohistochemical study of immature neurons in the subgranular zone of the rat dentate gyrus. Biophysics, 54 (4), 497–512.

Popov V. Stewart M.G. (2009)  Complexity of Contacts Between Synaptic Boutons and Dendritic Spines in Adult Mammalian Hippocampus: Three-Dimensional Reconstructions from Serial Ultrathin Sections in vivo" Synapse 63: 369–377

Medvedev N.I., Popov V. I., Rodriguez Arellano, J.J, Dallérac, G, Davies H.A., Gabbott, P.L, Laroche S., Kraev, I.V, Doyère V., Stewart M.G.(2010). The NMDA receptor antagonist CPP alters synapse and spine structure and impairs LTP and LTD induced morphological plasticity in dentate gyrus of the awake rat Neuroscience, 165(4) 1170-1181

Kraev, Igor; Henneberger, Christian; Rossetti, Clara; Conboy, Lisa; Kohler, Lene B.; Fantin, Martina; Jennings, Alistair; Venero, Cesar; Popov, Victor; Rusakov, Dmitri; Stewart, Michael; Bock, Elisabeth; Berezin, Vladimir and Sandi, Carmen (2011). A peptide mimetic targeting trans-homophilic NCAM binding sites promotes spatial learning and neural plasticity in the hippocampus. PLOS One, 6(8), e23433.

Michaluk, Piotr; Wawrzyniak, Marcin; Alot, Przemyslaw; Szczot, Marcin; Wyrembek, Paulina; Mercik, Katarzyna; Medvedev, Nikolay; Wilczek, Ewa; De Roo, Mathias; Zuschratter, Werner; Muller, Dominique; Wilczynski, Grzegorz M; Mozrzymas, Jerzy W; Stewart, Michael G.; Kaczmarek, Leszek and Wlodarczyk, Jakub (2011). Influence of matrix metalloproteinase MMP-9 on dendritic spine morphology. Journal of cell science, 124(Pt 19), pp. 3369–3380.

Ojo, Bunmi; Rezaie, Payam; Gabbott, Paul L.; Cowely, Thelma R.; Medvedev, Nikolay I.; Lynch, Marina A. and Stewart, Michael G. (2011). A neural cell adhesion molecule-derived peptide, FGL, attenuates glial cell activation in the aged hippocampus. Experimental Neurology, 323(2), pp. 318–328.

Popov, Victor I.; Kleschevnikov, Alexander M.; Klimenko, Oleg A.; Stewart, Michael G. and Belichenko, Pavel V. (2011). Three-dimensional synaptic ultrastructure in the dentate gyrus and hippocampal area CA3 in the Ts65Dn mouse model of down syndrome. Journal of Comparative Neurology, 519(7), pp. 1338–1354.

Witton, Jonathan; Padmashri, Ragunathan; Zinyuk, Larissa E.; Popov, Victor I.; Kraev, Igor; Line, Samantha J.; Jensen, Thomas P.; Tedoldi, Angelo; Cummings, Damian M.; Tybulewicz, Victor L. J.; Fisher, Elizabeth M. C.; Bannerman, David M.; Randall, Andrew D.; Brown, Jonathan T.; Edwards, Frances A.; Rusakov, Dmitri A.; Stewart, Michael G. and Jones, Matt W. (2015). Hippocampal circuit dysfunction in the Tc1 mouse model of Down syndrome. Nature Neuroscience Early Access.

Giese, Karl Peter; Aziz, Wajeeha; Kraev, Igor and Stewart, Michael G. (2015). Generation of multi-innervated dendritic spines as a novel mechanism of long-term memory formation. Neurobiology of Learning and Memory (Early view).

Medvedev, Popov, Henneberger, Rodsakov and Stewart M.G.  et al 2014 Glia selectively approach synapses on thin dendritic spines Phil. Trans. R. Soc. B 2014 369, 20140047

Rusakov, DA, Bard, L, Stewart MG & Henneberger C, (2014) Diversity of astroglial functions alludes to subcellular specialization. TRENDS IN NEUROSCIENCE 37(4):228-42. doi: 10.101/j.tins.2014.02.008

Kraev, IV., Doyere, V., Stewart, M.G. (2014) Multiple spine boutons are formed after long-lasting LTP  in the awake rat. Brain Struct Funct 219, (1) ,  407-414; DOI 10.1007/s00429-012-0488-0

Maurin, H, Chong, SA, Kraev,I., Davies, , Kremer, A., Seymour,C.M, Lechat, B., Jaworski, T., Borghgraef, P., Devijver, H.,  Callewaert, G., Stewart, M.G., Van Leuven, F. (2014) Early Structural and Functional Defects in Synapses and Myelinated Axons in Stratum Lacunosum Moleculare in Two Preclinical Models for Tauopathy. PLOS One DOI: 10.1371/journal.pone.0087605

Van der Kooij MA, Fantin M, Kraev I, Korshunova I, Grosse J, Zanoletti O, Guirado R, Garcia-Mompó C, Nacher J, Stewart MG, Berezin V, Sandi C. (2013) Impaired Hippocampal Neuroligin-2 Function by Chronic Stress or Synthetic Peptide Treatment is Linked to Social Deficits and Increased Aggression. Neuropsychopharmacology. 2013 Nov 11. doi: 10.1038/npp.2013.315.

   

Teaching interests

S22, COMPARATIVE PHYSIOLOGY , 1978 - 1980 - Maintenance chairman half-credit Course; Exam Board member 1978 – 1980; Residential School Line manager 1978-80
S202, BIOLOGY: FORM AND FUNCTION  Maintenance chairman full credit course, 1981 to 1989; Exam Board chairman -1981-88; Residential School Line manager 1981-84
S203 BIOLOGY: FORM AND FUNCTION , full credit course- 1987-1990
Production Course Chair and General Editor ; Chair of S203 Co-publication Group - Responsibility for external publication in collaboration with Hodder & Stoughton); Summer school experiment development; Exam Board chairman 1991- to 1995; hair of S203 Broadcast Sub-Group: 30 TV programmes, supported by co-production funds from Encyclopaedia Britannica;
SK220 HUMAN BIOLOGY AND HEALTH - Production Course Team Chair 1994-1997
Maintenance Course Team Chair 1997 on , Exam Board Chair 1997 on, Chair of SK220 Broadcast Sub-Group
S321 - PHYSIOLOGY OF CELLS AND ORGANISMS- (1977 - 1980)
S324- ANIMAL PHYSIOLOGY (1982 - 1984)- Course team member and Unit Author Book 2
            Member of maintenance    course team (1984 - 1988)
SD206 - BIOLOGY, BRAIN AND BEHAVIOUR (1992 on) -Production of "Brain Video" funded both externally and by the Open University.
SD226 Course team member and exam Board chair
DS871 - DS871 Exploring cognition: damaged brains and neural networks, Exam board chair
SK123 Understanding Cancer-Exam board chair
 

 

 

 

Research Activity

Research groups

NameTypeParent Unit
Biomedical Research Network (BRN)NetworkFaculty of Science

Publications

Auditory responses in a rodent model of Attention Deficit Hyperactivity Disorder (2015-12)
Brace, Louise R.; Kraev, Igor; Rostron, Claire L.; Stewart, Michael G. ; Overton, Paul G. and Dommett, Eleanor J.
Brain Research, 1629 (pp. 10-25)
Generation of multi-innervated dendritic spines as a novel mechanism of long-term memory formation (2015-10)
Giese, Karl Peter; Aziz, Wajeeha; Kraev, Igor and Stewart, Michael G.
Neurobiology of Learning and Memory, 124 (pp. 48-51)
Ultrastructural Changes in the White and Gray Matter of Mice at Chronic Time Points After Repeated Concussive Head Injury (2015-10)
Ojo, Joseph O.; Bachmeier, Corbin; Mouzon, Benoit C.; Tzekov, Radouil; Mullan, Michael; Davies, Heather; Stewart, Michael and Crawford, Fiona
Journal of Neuropathology & Experimental Neurology, 74(10) (pp. 1012-1035)
Altered visual processing in a rodent model of Attention-Deficit Hyperactivity Disorder (2015-09-10)
Brace, L. R.; Kraev, I.; Rostron, C. L.; Stewart, M. G.; Overton, P. G. and Dommett, E. J.
Neuroscience, 303 (pp. 364-377)
Impact of age-related neuroglial cell responses on hippocampal deterioration (2015-04-29)
Ojo, Joseph O.; Rezaie, Payam; Gabbott, Paul and Stewart, Michael G.
Frontiers in Aging Neuroscience, 7, Article 57
Hippocampal circuit dysfunction in the Tc1 mouse model of Down syndrome (2015)
Witton, Jonathan; Padmashri, Ragunathan; Zinyuk, Larissa E.; Popov, Victor I.; Kraev, Igor; Line, Samantha J.; Jensen, Thomas P.; Tedoldi, Angelo; Cummings, Damian M.; Tybulewicz, Victor L. J.; Fisher, Elizabeth M. C.; Bannerman, David M.; Randall, Andrew D.; Brown, Jonathan T.; Edwards, Frances A.; Rusakov, Dmitri A.; Stewart, Michael G. and Jones, Matt W.
Nature Neuroscience, 18 (pp. 1291-1298)
Glia selectively approach synapses on thin dendritic spines (2014-10)
Medvedev, Nikolay; Popov, Victor; Henneberger, Christian; Kraev, Igor; Rusakov, Dmitri and Stewart, Michael
Philosophical Transactions of the Royal Society B, 369, Article 20140047(1654)
Impaired hippocampal Neuroligin-2 Function by chronic stress or synthetic peptide treatment is linked to social deficits and increased aggression (2014-04)
van der Kooij, Michael A.; Fantin, Martina; Kraev, Igor; Korshunova, Irina; Grosse, Jocelyn; Zanoletti, Olivia; Guirado, Ramon; Garcia-Mompó, Clara; Nacher, Juan; Stewart, Michael; Berezin, Vladimir and Sandi, Carmen
Neuropsychopharmacology, 39(5) (pp. 1148-1158)
Diversity of astroglial functions alludes to subcellular specialisation (2014-03-13)
Rusakov, Dimitri A.; Bard, Lucie; Stewart, Michael G. and Henneberger, Christian
Trends in Neuroscience, 1043
Early structural and functional defects in synapses and myelinated axons in stratum lacunosum moleculare in two preclinical models for tauopaty (2014-02-03)
Maurin, Hervé; Chong, Seon-Ah; Kraev, Igor; Davies, Heather; Kremer, Anna; Seymour, Claire Marie; Lechat, Benoit; Jaworski, Tomasz; Borghgraef, Peter; Devijver, Herman; Callewaert, Geert; Stewart, Michael G. and Van Leuven, Fred
PLoS ONE
Multiple spine boutons are formed after long-lasting LTP in the awake rat (2014)
Medvedev, Ni. I.; Dallérac, G.; Popov, V. I.; Rodriguez Arellano, J. J.; Davies, H. A.; Kraev, I. V.; Doyère, V. and Stewart, M. G.
Brain Structure & Function, 219(1) (pp. 407-414)
Amyloid-beta induced CA1 pyramidal cell loss in young adult rats is alleviated by systemic treatment with FGL, a neural cell adhesion molecule-derived mimeticPeptide (2013-08-09)
Corbett, Nicola J.; Gabbott, Paul L.; Klementiev, Boris; Davies, Heather A.; Colyer, Frances M.; Novikova, Tatiana and Stewart, Michael G.
PLOS One, 8, Article e71479(8)
An NCAM mimetic, FGL, alters hippocampal cellular morphometry in young adult (4 month-old) rats (2013)
Ojo, Bunmi; Gabbott, Paul L.; Rezaie, Payam; Corbett, Nicola; Medvedev, Nikolay I.; Cowley, Thelma R.; Lynch , Marina and Stewart, Michael G.
Neurochemical Research, 38, Article PMID: 23076631 (6) (pp. 1208-1218)
Age-related changes in the hippocampus (loss of synaptophysin and glial-synaptic interaction) are modified by systemic treatment with an NCAM-derived peptide, FGL (2012-07)
Ojo, Bunmi; Rezaie, Payam; Gabbott, Paul; Davies, Heather; Colyer, Frances; Cowley, Thelma R.; Lynch, Marina and Stewart, Michael
Brain, Behavior, and Immunity, 26(5) (778- 788)
Visual deprivation alters dendritic bundle architecture in layer 4 of rat visual cortex (2012-04-06)
Gabbott, P. L. and Stewart, M. G.
Neuroscience, 207 (pp. 65-77)
A neural cell adhesion molecule-derived peptide, FGL, attenuates glial cell activation in the aged hippocampus (2011-12)
Ojo, Bunmi; Rezaie, Payam; Gabbott, Paul L.; Cowely, Thelma R.; Medvedev, Nikolay I.; Lynch, Marina A. and Stewart, Michael G.
Experimental Neurology, 232(2) (pp. 318-328)
Forebrain CRF1 modulates early-life stress-programmed cognitive deficits (2011-09-21)
Wang, Xiao-Dong; Rammes, Gerhard; Kraev, Igor; Wolf, Miriam; Liebl, Claudia; Scharf, Sebastian. H.; Rice, Courtney. J.; Wurst, Wolfgang; Holsboer, Florian; Deussing, Jan. M.; Baram, Tallie. Z.; Stewart, Michael. G.; Muller, Marianne. B. and Schmidt, Mathias. V.
Journal of Neuroscience, 31(38) (pp. 13625-13634)
A peptide mimetic targeting trans-homophilic NCAM binding sites promotes spatial learning and neural plasticity in the hippocampus (2011-08)
Kraev, Igor; Henneberger, Christian; Rossetti, Clara; Conboy, Lisa; Kohler, Lene B.; Fantin, Martina; Jennings, Alistair; Venero, Cesar; Popov, Victor; Rusakov, Dmitri; Stewart, Michael; Bock, Elisabeth; Berezin, Vladimir and Sandi, Carmen
PLoS ONE, 6(8) (e23433)
Three-dimensional synaptic ultrastructure in the dentate gyrus and hippocampal area CA3 in the Ts65Dn mouse model of down syndrome (2011-05-01)
Popov, Victor I. ; Kleschevnikov, Alexander M.; Klimenko, Oleg A.; Stewart, Michael G. and Belichenko, Pavel V.
Journal of Comparative Neurology, 519(7) (pp. 1338-1354)
Suspension of mitotic activity in dentate gyrus of the hibernating ground squirrel (2011)
Popov, Victor; Kraev, Igor V.; Ignat'ev, Dimitri and Stewart, Michael G.
Neural Plasticity, 2011
Influence of matrix metalloproteinase MMP-9 on dendritic spine morphology (2011)
Michaluk, Piotr; Wawrzyniak, Marcin; Alot, Przemyslaw; Szczot, Marcin; Wyrembek, Paulina; Mercik, Katarzyna; Medvedev, Nikolay; Wilczek, Ewa; De Roo, Mathias; Zuschratter, Werner; Muller, Dominique; Wilczynski, Grzegorz M; Mozrzymas, Jerzy W; Stewart, Michael G.; Kaczmarek, Leszek and Wlodarczyk, Jakub
Journal of cell science, 124(Pt 19) (pp. 3369-3380)
Tumor suppressor down-regulated in renal cell carcinoma 1 (DRR1) is a stress-induced actin bundling factor that modulates synaptic efficacy and cognition (2011)
Schmidt, Mathias V.; Schülke, Jan-Philip; Liebl, Claudia; Stiess, Michael; Avrabos, Charilaos; Bock, Jörg; Wochnik, Gabriela M.; Davies, Heather A.; Zimmermann, Nicole; Scharf, Sebastian H.; Trümbach, Dietrich; Wurst, Wolfgang; Zieglgänsberger, Walter; Turck, Christoph; Holsboer, Florian; Stewart, Michael G.; Bradke, Frank; Eder, Matthias; Müller, Marianne B. and Rein, Theo
Proceedings of the National Academy of Sciences of the United States of America, 108(41) (pp. 17213-17218)
Mechanism for long-term memory formation when synaptic strengthening is impaired (2011)
Radwanska , Kasia; Medvedev, Nikolay I.; Pereira, Grace S. ; Engmann, Olivia; Thiede, Nina; Moraes, Marcio F. D.; Villiers, Agnes; Irvine, Elaine E.; Maunganidze, Nicollett S.; Pyza, Elzbieta M.; Ris, Laurence; Szymańska, Magda ; Lipiński, Michał ; Kaczmarek, Leszek ; Stewart, Michael G. and Giese, K. Peter
PNAS, 108(45) (pp. 18471-18475)
Alterations in synaptic curvature in the dentate gyrus following induction of long-term potentiation, long-term depression, and treatment with the N-methyl-d-aspartate receptor antagonist CPP (2010-09-16)
Medvedev, N. I.; Popov, V. I.; Dallérac, G.; Davies, H. A.; Laroche, S.; Kraev, I. V.; Roriguez Arellano, J. J.; Doyère, V. and Stewart, M. G.
Neuroscience, 171(2) (pp. 309-397)
The N-methyl-d-aspartate receptor antagonist CPP alters synapse and spine structure and impairs long-term potentiation and long-term depression induced morphological plasticity in dentate gyrus of the awake rat (2010-02)
Medvedev, N. I.; Popov, V. I.; Rodriguez Arellano, J. J.; Dallérac, G.; Davies, H. A.; Gabbott, P. L.; Laroche, S.; Kraev, I. V.; Doyère, V. and Stewart, M. G.
Neuroscience, 165(4) (pp. 1170-1181)
New insight into mode of action of Colostrinin (2010)
Stewart, Michael G.
Journal of Nutrition, Health and Aging, 14(4) (pp. 336-336)
Colostrinin™ alleviates amyloid-β induced toxicity in rat primary hippocampal cultures (2010)
Froud, Kristina E.; Wardhaugh, Tina; Banks, Duncan; Saffrey, M. Jill and Stewart, Michael G.
Journal of Alzheimer's Disease, 20(2) (pp. 423-426)
A subpopulation of serotonin1B receptors colocalize with the AMPA receptor subunit GluR2 in the hippocampal dentate gyrus (2010)
Peddie, C. J.; Davies, H. A.; Colyer, F M.; Stewart, M. G. and Rodríguez, J. J.
Neuroscience Letters, 485(3) (pp. 251-255)
Three-dimensional ultrastructural and immunohistochemical study of immature neurons in the subgranular zone of the rat dentate gyrus (2009-08)
Popov, V. I.; Kraev, I. V.; Banks, D.; Davies, H. A.; Morenkov, E. D.; Stewart, M. G. and Fesenko, E. E.
Biophysics, 54(4) (pp. 497-512)
Complexity of contacts between synaptic boutons and dendritic spines in adult rat hippocampus: Three-dimensional reconstructions from serial ultrathin sections in vivo (2009)
Stewart, Michael G. and Popov, Victor I.
Synapse, 63(5) (pp. 369-377)
N-methyl-d-aspartate receptor independent changes in expression of polysialic acid-neural cell adhesion molecule despite blockade of homosynaptic long-term potentiation and heterosynaptic long-term depression in the awake freely behaving rat dentate gyrus (2009)
Rodríguez, J. J.; Dallérac, G. M.; Tabuchi, M.; Davies, H. A.; Colyer, F. M.; Stewart, M. G. and Doyère, V.
Neuron Glia Biology, 4(3) (pp. 169-178)
Partial kindling induces neurogenesis, activates astrocytes and alters synaptic morphology in the dentate gyrus of freely moving adult rats (2009)
Kraev, Igor; Godukhin, Oleg V.; Patrushev, Ilya V.; Davies, Heather A.; Popov, Victor I. and Stewart, Michael G.
Neuroscience, 162(2) (pp. 254-267)
Dendritic colocalisation of serotonin1B receptors and the glutamate NMDA receptor subunit NR1 within the hippocampal dentate gyrus: An ultrastructural study (2008-09)
Peddie, C.J.; Davies, H.A.; Colyer, F.M.; Stewart, M.G. and Rodriguez, J.J.
Journal of Chemical Neuroanatomy, 36(1) (pp. 17-26)
FG-Loop, a fibroblast growth factor receptor agonist, inactivates upregulated glycogen synthase kinase 3 beta in the CA1 of a beta-amyloid treated rat hippocampus (2008-07)
Corbett, Nicola; Gabbott, Paul; Klementiev, Boris; Davies, Heather; Colyer, Frances; Novikova, Tatiana; Berezin, Vladimir; Bock, Elisabeth and Stewart, Michael
FENS Forum Abstracts, 4(149.7)
Colocalisation of serotonin2A receptors with the glutamate receptor subunits NR1 and GluR2 in the dentate gyrus: An ultrastructural study of a modulatory role (2008-06)
Peddie, C.J.; Davies, H.A.; Colyer, F.M.; Stewart, M.G. and Rodriguez, J.J.
Experimental Neurology, 211(2) (pp. 561-573)
ARG3.1/ARC expression in hippocampal dentate gyrus astrocytes: ultrastructural evidence and co-localization with glial fibrillary acidic protein (2008-04)
Rodriguez, J. J.; Davies, H. A.; Errington, M. L.; Verkhratsky, A.; Bliss, T. V. P. and Stewart, M. G.
Journal of Cellular and Molecular Medicine, 12(2) (pp. 671-678)
The glutamate receptor 2 subunit controls post-synaptic density complexity and spine shape in the dentate gyrus (2008-01)
Medvedev, Nikolay I.; Rodriguez-Arellano, Jose J.; Popov, Victor I.; Davies, Heather; Tigaret, Cezar M.; Schoepfer, Ralf and Stewart, Michael
European Journal of Neuroscience, 27(2) (pp. 315-325)
A cell adhesion molecule mimetic, FGL peptide, induces alterations in synapse and dendritic spine structure in the dentate gyrus of aged rats: a three-dimensional ultrastructural study (2008)
Popov, Victor I.; Medvedev, Nikolay I.; Kraev, Igor V.; Gabbott, Paul L.; Davies, Heather A.; Lynch, Marina; Cowley, Thelma R.; Berezin, Vladmir; Bock, Elisabeth and Stewart, Michael
European Journal of Neuroscience, 27(2) (pp. 301-314)
Colostrinin: a naturally occurring compound derived from mammalian colostrum with efficacy in treatment of neurodegenerative diseases, including Alzheimer's (2008)
Stewart, Michael
Expert Opinion on Pharmacotherapy, 9(14) (pp. 2553-2559)
A neural cell adhesion molecule mimetic, FG Loop (FGL), alleviates spine loss induced by beta-amyloid(25-35) in the rat hippocampus (2007-11)
Corbett, Nicola; Gabbott, Paul; Stewart, Michael; Klementiev, Boris; Davies, Heather; Colyer, Frances; Novikova, Tatiana; Bock, Elisabeth and Berezin, Vladimir
Society for Neuroscience Abstracts(886.9)
Reversible reduction in dendritic spines in CA1 of rat and ground squirrel subjected to hypothermia–normothermia in vivo: A three-dimensional electron microscope study (2007-11)
Popov, V.I.; Medvedev, N.I.; Patrushev, I.V.; Ignat'ev, D.A.; Morenkov, E.D. and Stewart, M.G.
Neuroscience, 149(3) (pp. 549-560)
A fibroblast growth factor receptor 1 agonist reduces the loss of hippocampal dendritic spines caused by beta-amyloid(25-35) (2007-04)
Corbett, Nicola; Stewart, Michael; Gabbott, Paul; Klementiev, Boris; Davies, Heather; Colyer, Frances; Berezin, Vladimir and Bock, Elisabeth
British Neuroscience Association Abstracts, 19(57.16)
The effect of a fibroblast growth factor receptor agonist on the beta-amyloid(25-35) treated hippocampus (2007-04)
Corbett, Nicola; Stewart, Michael; Gabbott, Paul; Klementiev, Boris; Davies, Heather; Colyer, Frances; Berezin, Vladimir and Bock, Elisabeth
British Neuroscience Association Abstracts, 19(43.03)
Manipulating Kv4.2 identifies a specific component of hippocampal pyramidal neuron A-current that depends upon Kv4.2 expression (2006-11)
Lauver, Aaron; Yuan, Li-Lian; Jeromin, Andreas; Nadin, Brian M.; Rodriguez, Jose J.; Davies, Heather A.; Stewart, Michael G.; Wu, Gang-Yi and Pfaffinger, Paul J.
Journal of Neurochemistry, 99(4) (pp. 1207-1223)
Enhancement of long-term memory retention by Colostrinin in one-day-old chicks trained on a weak passive avoidance learning paradigm (2006-07)
Stewart, Michael G. and Banks, Duncan
Neurobiology of Learning and Memory, 86(1) (pp. 66-71)
Passive avoidance training decreases synapse density in the hippocampus of the domestic chick (2006-02-23)
Nikolakopoulou, A.M.; Davies, H.A. and Stewart, M.G.
European Journal of Neuroscience, 23(4) (pp. 1054-1062)
Subunit dependencies of N-methyl-D-aspartate (NMDA) receptor-induced alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor internalization (2006-01-25)
Tigaret, C.M.; Thalhammer, A.; Rast, G.F.; Specht, C.G.; Auberson, Y.P.; Stewart, M.G. and Schoepfer, R.
Molecular Pharmacology, 69(4) (pp. 1251-1259)
Passive avoidance training is correlated with decreased cell proliferation in the chick hippocampus (2006)
Nikolakopoulou, A. M; Dermon, C. R.; Panagis, L.; Pavlidis, M. and Stewart, M. G.
European Journal of Neuroscience, 24(9) (pp. 2631-2642)
Mitochondria form a filamentous reticular network in hippocampal dendrites but are present as discrete bodies in axons: a three-dimensional ultrastructural study (2005-11-07)
Popov, Victor; Medvedev, Nikolai I.; Davies, Heather A. and Stewart, Michael G.
Journal of Comparative Neurology, 492(1) (pp. 50-65)
Chemically induced long-term potentiation increases the number of peforated and complex postsynaptic densities but does not alter dendritic spine volume in CA1 of adult mouse hippocampal slices (2005-06)
Stewart, M. G.; Medvedev, N. I.; Popov, V. I.; Schoepfer, R.; Davies, H. A.; Murphy, K.; Dallerac, G. M.; Kraev, I. V. and Rodriguez, J. J.
European Journal of Neuroscience, 21(12) (pp. 3368-3378)
Three-dimensional reconstruction of synapses and dendritic spines in the rat and ground squirrel hippocampus: New structural-functional paradigms for synaptic function (2005-05)
Popov, V. I.; Deev, A. A.; Klimenko, O. A.; Kraev, I. V.; Kuz'minykh, S. B.; Medvedev, N. I.; Patrushev, I. V.; Popov, R. V.; Rogachevskii, V. V.; Khutsiyan, S. S.; Stewart, M. G. and Fesenko, E. E.
Neuroscience and Behavioral Physiology, 35(4) (pp. 333-341)
Long-term potentiation in the rat dentate gyrus is associated with enhanced Arc/Arg3.1 protein expression in spines, dendrites and glia (2005-05)
Rodríguez, J. J.; Davies, H. A.; Silva, A. T.; De Souza, I. E. J.; Peddie, C. J.; Colyer, F. M.; Lancashire, C. L.; Fine, A.; Errington, M. L.; Bliss, T. V. P. and Stewart, M. G.
European Journal of Neuroscience, 21(9) (pp. 2384-2396)
Pregnenolone sulfate enhances neurogenesis and PSA-NCAM in young and aged hippocampus (2005-01)
Mayoa, W.; Lemaire, V; Malaterre, J.; Rodriguez, J. J.; Cayre, M.; Stewart, M. G.; Kharouby, M.; Rougon, G.; Le Moal, M.; Piazza, P. V. and Abrous, D. N.
Neurobiology of Aging, 26(1) (pp. 103-114)
Structural basis of hippocampal plasticity following stress and learning: Electron microscopical studies (2005)
Stewart, M. G.
Acta Neurobiologiae Experimentalis, 65(3) (p 305)
Chronic restraint stress down-regulates amygdaloid expression of polysialylated neural cell adhesion molecule (2005)
Cordero, M. I.; Rodriguez, J. J.; Davies, H. A.; Peddie, C. J.; Sandi, C. and Stewart, M. G.
Neuroscience, 133(4) (pp. 903-910)
Stress suppresses and learning induces plasticity in CA3 of rat hippocampus: a three-dimensional ultrastructural study of thorny excrescences and their postsynaptic densities (2005)
Stewart, M. G.; Davies, H. A.; Sandi, C.; Kraev, I. V.; Rogachevsky, V. V.; Peddie, C. J.; Rodriguez, J. J.; Cordero, M. I.; Donohue, H. S.; Gabbott, P. L. and Popov, V. I.
Neuroscience, 131(1) (pp. 43-54)
Inhibiting effect of D1, but not D2 antagonist administered to the striatum on retention of passive avoidance in the chick (2004-03)
Kabai, Peter; Stewart, Michael G.; Tarcali, József and Csillag, András
Neurobiology of Learning and Memory, 81(2) (pp. 155-158)
Expression of long-term potentiation in aged rats involves perforated synapses but dendritic spine branching results from high-frequency stimulation alone (2004)
Dhanrajan, Tiruchinapalli M.; Lynch, Marina A.; Kelly, Aine; Popov, Victor I.; Rusakov, Dmitri A. and Stewart, Michael
Hippocampus, 14(2) (pp. 255-264)
Remodelling of synaptic morphology but unchanged synaptic density during late phase long-term potentiation (LTP): a serial section electron micrograph study in the dentate gyrus in the anaesthetised rat (2004)
Popov, V.I.; Davies, H.A.; Rogachevsky, V.V.; Patrushev, I.V.; Errington, M.L.; Gabbott, P.L.A.; Bliss, T.V.P. and Stewart, M.G.
Neuroscience, 128(2) (pp. 251-262)
Long-term synaptic morphometry changes after induction of long-term potentiation and long-term depression in the dentate gyrus of awake rats are not simply mirror phenomena (2004)
Mezey, Szilvia; Doyere, Valérie; Souza, Ian De and Stewart, Michael
European Journal of Neuroscience, 19(8) (pp. 2310-2318)
Synaptophysin immunogold labelling of synapses decreases in dentate gyrus of the hippocampus of aged rats (2003-10)
Davies, H. A.; Kelly, A.; Dhanrajan, T. M.; Lynch, M. A. and Stewart, M. G.
Brain Research, 986(1-2) (pp. 191-195)
Rapid reversal of stress induced loss of synapses in CA3 of rat hippocampus following water maze training (2003-06)
Sandi, Carmen; Davies, Heather; Isabel Cordero, M.; Rodriguez, Jose J.; Popov, Victor I. and Stewart, Michael G.
European Journal of Neuroscience, 17(11) (pp. 2447-2456)
Morphological changes in hippocampal dentate gyrus synapses following spatial learning in rats are transient (2003-05)
Eyre, Mark D.; Richter-Levin, Gal; Avital, Avi and Stewart, Michael G.
European Journal of Neuroscience, 17(9) (pp. 1973-1980)
The three-dimensional organization of synapses and astroglia in the hippocampus of rat and ground squirrel: New paradigms of synapse structure and function (2003-03)
Popov, V. I.; Medvedev, N. I.; Rogachevskii, V. V.; Ignatev, D. A.; Stewart, M. G. and Fesenko, E E
Biophysics, 48(2) (pp. 289-308)
Ultrastructural and behavioural changes precede amyloid deposition in a transgenic model of Alzheimer’s disease (2003)
Richardson, J.C.; Kendal, C.E.; Anderson, R.; Priest, F.; Gower, E.; Soden, P.; Gray, R.; Topps, S.; Howlett, D.R.; Lavendar, D.; Clarke, N.J.; Barnes, J.C.; Haworth, R.; Stewart, M.G. and Rupniak, H.T.R.
Neuroscience, 122 (pp. 213-228)
Passive avoidance training enhances cell proliferation in 1-day-old chicks (2002-10)
Dermon, C. R.; Zikopolous, B.; Panagis, L.; Harrison, E.; Lancashire, C. L.; Mileusnic, R. and Stewart, M.G.
European Journal of Neuroscience, 16(7) (pp. 1267-1274)
Ultrastructural Distribution of the 7 Nicotinic Acetylcholine Receptor Subunit in Rat Hippocampus (2001-10-15)
Fabian Fine, Ruth; Skehel, Paul; Errington, Mick L.; Davies, Heather A.; Sher, Emanuele; Stewart, Michael G. and Fine, Alan
Journal of Neuroscience, 21(20) (pp. 7993-8003)
Morphological studies of synaptic plasticiy and learning in rat hippocampus (2001)
Stewart, Michael; Eyre, M. D. and Richter-Levin, G.
Neural Plasticity, 8(3) (pp. 203-203)
Structure and complexity of the synapse and dendritic spine (2014-01-29)
Stewart, Michael G.; Popov, Victor I.; Kraev, Igor V.; Medvedev, Nikolay and Davies, Heather A.
In: Pickel, Virginia and Segal, Menahem eds. The Synapse: Structure and Function. Neuroscience-Net Reference Book Series (3) (pp. 1-20)
ISBN : 978-0-12-418675-0 | Publisher : Academic Press | Published : Kidlington
Structural synaptic and dendritic spine plasticity in the hippocampus (2012-06-12)
Stewart, Michael and Popov, Victor
In: Giese, Karl Peter ed. Memory Mechanisms In Health And Disease: Mechanistic Basis of Memory. Neurology/ Neuroscience (pp. 19-52)
ISBN : 978-981-4366-69-4 | Publisher : World Scientific Publishing Co. | Published : London
Structure and complexity of the synapse and dendritic spine (2012-05-15)
Stewart, Michael; Popov, Victor; Kraev, Igor; Medvedev, Nikolay and Davies, Heather
In: Pickel, Virginia and Segal, Menahem eds. The Synapse: Structure and Function. Neuroscience-Net Master Reference Book Series (MRBS) (pp. 1-20)
Publisher : Neuroscience-Net LLC | Published : New York
Dendritic spine and synapse morphological alterations induced by a neural cell adhesion molecule mimetic (2010)
Stewart, Michael; Popov, Victor; Medvedev, Nikolay; Gabbott, Paul; Corbett, Nicola; Kraev, Igor and Davies, Heather
In: Berezin, Vladimir ed. Structure and Function of the Neural Cell Adhesion Molecule NCAM. Advances in Experimental Medicine and Biology (pp. 373-383)
ISBN : 978-1-4419-1169-8 | Publisher : Springer | Published : New York
The protective effect of colostrinin CLN(TM) against beta-amyloid and an oxidative stress inducer, menadione, in primary hippocampal cultures (2008)
Froud, K.; Saffrey, M. J.; Stewart, M. G.; Banks, D. and Wardhaugh, T.
In : FENS Forum 2008 (12-16 Jul 2008, Geneva)
Investigation of the mechanism of action of Colostrinin(TM) on neurons in culture (2006-07)
Froud, K. E.; Wardhaugh, T.; Stewart, M. G.; Banks, D. and Saffrey, M. J.
In : 5th Forum of European Nueroscience (July 8-12, 2006, Vienna, Austria)

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