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Dr Kaustubh Adhikari

Kaustubh Adhikari

Profile summary

Web links

Professional biography

PhD in Biostatistics, Harvard University.
M.Sc. in Biostatistics, Harvard University.
M.Stat. in Statistics, Indian Statistical Institute.
B.Stat. in Statistics, Indian Statistical Institute.

Postdoctoral Research Associate, University College London.

Research interests

The main area of my research is Statistical Genetics. My research interests on human genetics can be split into two major avenues:  

  • Population genetics of admixed human populations, such as Latin America and South Asia.
  • The genetics of human appearance and normal physical variation, such as facial morphology or pigmentation. I study these through genome-wide association studies (GWAS), and build prediction models for forensic reconstruction.

In these contexts, I study signals of natural selection and evolution, such as the evolution of light skin in Eurasia. 

I’m looking into developing computational methods to address big data problems in high-dimensional genetic and phenotypic data.

A key focus of my work is increasing the diversity of genetics research, by looking at other diverse human populations outside of the Eurocentric emphasis in most GWAS studies

Impact and engagement

I have a keen interest in public engagement on statistics and statistical genetics, in particular about their misuse and misunderstandings. 

  • I am the Statistics consultant for the BBC radio program ‘More or Less’.
  • I present Masterclasses on Statistics at the Royal Institution.
  • I have written popular science articles at The Conversation and on OpenLearn.
  • My forensics research have been featured on ‘DNA+’, a BBC documentary exploring modern genetics.

Publications

Novel genetic loci affecting facial shape variation in humans (2019-11-26)
Xiong, Ziyi; Dankova, Gabriela; Howe, Laurence J.; Lee, Myoung Keun; Hysi, Pirro G.; de Jong, Markus A.; Zhu, Gu; Adhikari, Kaustubh; Li, Dan; Li, Yi; Pan, Bo; Feingold, Eleanor; Marazita, Mary L.; Shaffer, John R.; McAloney, Kerrie; Xu, Shu-Hua; Jin, Li; Wang, Sijia; de Vrij, Femke M. S.; Lendemeijer, Bas; Richmond, Stephen; Zhurov, Alexei; Lewis, Sarah; Sharp, Gemma C.; Paternoster, Lavinia; Thompson, Holly; Gonzalez-Jose, Rolando; Bortolini, Maria Catira; Canizales-Quinteros, Samuel; Gallo, Carla; Poletti, Giovanni; Bedoya, Gabriel; Rothhammer, Francisco; Uitterlinden, André G.; Ikram, M. Arfan; Wolvius, Eppo; Kushner, Steven A.; Nijsten, Tamar E. C.; Palstra, Robert-Jan T. S.; Boehringer, Stefan; Medland, Sarah E.; Tang, Kun; Ruiz-Linares, Andrés; Martin, Nicholas G.; Spector, Timothy D.; Stergiakouli, Evie; Weinberg, Seth M.; Liu, Fan and Kayser, Manfred
eLife, 8 (pp. 1-32)


Modeling Population Structure Under Hierarchical Dirichlet Processes (2019-05-19)
Elliott, Lloyd T.; De Iorio, Maria; Favaro, Stefano; Adhikari, Kaustubh and Teh, Yee Whye
Bayesian Analysis, 14(2) (pp. 313-339)


Genetic components of human pain sensitivity: a protocol for a genome-wide association study of experimental pain in healthy volunteers (2019-04-20)
Schmid, Annina B.; Adhikari, Kaustubh; Ramirez-Aristeguieta, Luis Miguel; Chacón-Duque, Juan-Camilo; Poletti, Giovanni; Gallo, Carla; Rothhammer, Francisco; Bedoya, Gabriel; Ruiz-Linares, Andres and Bennett, David L
BMJ Open, 9(4) (e025530)


Variation in dental morphology and inference of continental ancestry in admixed Latin Americans (2019-03)
Delgado, Miguel; Ramírez, Luis Miguel; Adhikari, Kaustubh; Fuentes-Guajardo, Macarena; Zanolli, Clément; Gonzalez-José, Rolando; Canizales, Samuel; Bortolini, Maria-Catira; Poletti, Giovanni; Gallo, Carla; Rothhammer, Francisco; Bedoya, Gabriel and Ruiz-Linares, Andres
American Journal of Physical Anthropology, 168(3) (pp. 438-447)


A geometric morphometric approach to the study of variation of shovel-shaped incisors (2019-01)
Carayon, Delphine; Adhikari, Kaustubh; Monsarrat, Paul; Dumoncel, Jean; Braga, José; Duployer, Benjamin; Delgado, Miguel; Fuentes-Guajardo, Macarena; de Beer, Frikkie; Hoffman, Jakobus W.; Oettlé, Anna C.; Donat, Richard; Pan, Lei; Ruiz-Linares, Andres; Tenailleau, Christophe; Vaysse, Frédéric; Esclassan, Rémi and Zanolli, Clément
American Journal of Physical Anthropology, 168(1) (pp. 229-241)


Obesity, genomic ancestry, and socioeconomic variables in Latin American mestizos (2019)
Ruderman, Anahí; Pérez, Luis O.; Adhikari, Kaustubh; Navarro, Pablo; Ramallo, Virginia; Gallo, Carla; Poletti, Giovanni; Bedoya, Gabriel; Bortolini, Maria C.; Acuña-Alonzo, Victor; Canizales-Quinteros, Samuel; Rothhammer, Francisco; Ruiz-Linares, Andres and González-José, Rolando
American Journal of Human Biology, Article e23278. ((In press))


A GWAS in Latin Americans highlights the convergent evolution of lighter skin pigmentation in Eurasia (2019)
Adhikari, Kaustubh; Mendoza-Revilla, Javier; Sohail, Anood; Fuentes-Guajardo, Macarena; Lampert, Jodie; Chacón-Duque, Juan Camilo; Hurtado, Malena; Villegas, Valeria; Granja, Vanessa; Acuña-Alonzo, Victor; Jaramillo, Claudia; Arias, William; Lozano, Rodrigo Barquera; Everardo, Paola; Gómez-Valdés, Jorge; Villamil-Ramírez, Hugo; Silva de Cerqueira, Caio C.; Hunemeier, Tábita; Ramallo, Virginia; Schuler-Faccini, Lavinia; Salzano, Francisco M.; Gonzalez-José, Rolando; Bortolini, Maria-Cátira; Canizales-Quinteros, Samuel; Gallo, Carla; Poletti, Giovanni; Bedoya, Gabriel; Rothhammer, Francisco; Tobin, Desmond J.; Fumagalli, Matteo; Balding, David and Ruiz-Linares, Andrés
Nature Communications, 10, Article 358


Genome-wide association studies and CRISPR/Cas9-mediated gene editing identify regulatory variants influencing eyebrow thickness in humans (2018-09-24)
Wu, Sijie; Zhang, Manfei; Yang, Xinzhou; Peng, Fuduan; Zhang, Juan; Tan, Jingze; Yang, Yajun; Wang, Lina; Hu, Yanan; Peng, Qianqian; Li, Jinxi; Liu, Yu; Guan, Yaqun; Chen, Chen; Hamer, Merel A.; Nijsten, Tamar; Zeng, Changqing; Adhikari, Kaustubh; Gallo, Carla; Poletti, Giovanni; Schuler-Faccini, Lavinia; Bortolini, Maria-Cátira; Canizales-Quinteros, Samuel; Rothhammer, Francisco; Bedoya, Gabriel; González-José, Rolando; Li, Hui; Krutmann, Jean; Liu, Fan; Kayser, Manfred; Ruiz-Linares, Andres; Tang, Kun; Xu, Shuhua; Zhang, Liang; Jin, Li and Wang, Sijia
PLOS Genetics, 14, Article e1007640(9) (pp. 1-22)


Developmental pathways inferred from modularity, morphological integration and fluctuating asymmetry patterns in the human face (2018)
Quinto-Sánchez, Mirsha; Muñoz-Muñoz, Francesc; Gomez-Valdes, Jorge; Cintas, Celia; Navarro, Pablo; Cerqueira, Caio Cesar Silva de; Paschetta, Carolina; de Azevedo, Soledad; Ramallo, Virginia; Acuña-Alonzo, Victor; Adhikari, Kaustubh; Fuentes-Guajardo, Macarena; Hünemeier, Tábita; Everardo, Paola; de Avila, Francisco; Jaramillo, Claudia; Arias, Williams; Gallo, Carla; Poletti, Giovani; Bedoya, Gabriel; Bortolini, Maria Cátira; Canizales-Quinteros, Samuel; Rothhammer, Francisco; Rosique, Javier; Ruiz-Linares, Andres and Gonzalez-Jose, Rolando
Scientific Reports, 8, Article 963


Latin Americans show wide-spread Converso ancestry and imprint of local Native ancestry on physical appearance (2018)
Chacón-Duque, Juan-Camilo; Adhikari, Kaustubh; Fuentes-Guajardo, Macarena; Mendoza-Revilla, Javier; Acuña-Alonzo, Victor; Barquera, Rodrigo; Quinto-Sánchez, Mirsha; Gómez-Valdés, Jorge; Everardo Martínez, Paola; Villamil-Ramírez, Hugo; Hünemeier, Tábita; Ramallo, Virginia; Silva de Cerqueira, Caio C.; Hurtado, Malena; Villegas, Valeria; Granja, Vanessa; Villena, Mercedes; Vásquez, René; Llop, Elena; Sandoval, José R.; Salazar-Granara, Alberto A.; Parolin, Maria-Laura; Sandoval, Karla; Peñaloza-Espinosa, Rosenda I.; Rangel-Villalobos, Hector; Winkler, Cheryl A.; Klitz, William; Bravi, Claudio; Molina, Julio; Corach, Daniel; Barrantes, Ramiro; Gomes, Verónica; Resende, Carlos; Gusmão, Leonor; Amorim, Antonio; Xue, Yali; Dugoujon, Jean-Michel; Moral, Pedro; González-José, Rolando; Schuler-Faccini, Lavinia; Salzano, Francisco M.; Bortolini, Maria-Cátira; Canizales-Quinteros, Samuel; Poletti, Giovanni; Gallo, Carla; Bedoya, Gabriel; Rothhammer, Francisco; Balding, David; Hellenthal, Garrett and Ruiz-Linares, Andrés
Nature Communications, 9, Article 5388


Socioeconomic Status Is Not Related with Facial Fluctuating Asymmetry: Evidence from Latin-American Populations (2017)
Quinto-Sánchez, Mirsha; Cintas, Celia; Silva de Cerqueira, Caio Cesar; Ramallo, Virginia; Acuña-Alonzo, Victor; Adhikari, Kaustubh; Castillo, Lucía; Gomez-Valdés, Jorge; Everardo, Paola; De Avila, Francisco; Hünemeier, Tábita; Jaramillo, Claudia; Arias, Williams; Fuentes, Macarena; Gallo, Carla; Poletti, Giovani; Schuler-Faccini, Lavinia; Bortolini, Maria Cátira; Canizales-Quinteros, Samuel; Rothhammer, Francisco; Bedoya, Gabriel; Rosique, Javier; Ruiz-Linares, Andrés and González-José, Rolando
PLOS ONE, 12, Article e0169287(1)


A genome-wide association scan in admixed Latin Americans identifies loci influencing facial and scalp hair features (2016-03-01)
Adhikari, Kaustubh; Fontanil, Tania; Cal, Santiago; Mendoza-Revilla, Javier; Fuentes-Guajardo, Macarena; Chacón-Duque, Juan-Camilo; Al-Saadi, Farah; Johansson, Jeanette A.; Quinto-Sanchez, Mirsha; Acuña-Alonzo, Victor; Jaramillo, Claudia; Arias, William; Barquera Lozano, Rodrigo; Macín Pérez, Gastón; Gómez-Valdés, Jorge; Villamil-Ramírez, Hugo; Hunemeier, Tábita; Ramallo, Virginia; Silva de Cerqueira, Caio C.; Hurtado, Malena; Villegas, Valeria; Granja, Vanessa; Gallo, Carla; Poletti, Giovanni; Schuler-Faccini, Lavinia; Salzano, Francisco M.; Bortolini, Maria-Cátira; Canizales-Quinteros, Samuel; Rothhammer, Francisco; Bedoya, Gabriel; Gonzalez-José, Rolando; Headon, Denis; López-Otín, Carlos; Tobin, Desmond J.; Balding, David and Ruiz-Linares, Andrés
Nature Communications, 7, Article 10815(1)


A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation (2016)
Adhikari, Kaustubh; Fuentes-Guajardo, Macarena; Quinto-Sánchez, Mirsha; Mendoza-Revilla, Javier; Camilo Chacón-Duque, Juan; Acuña-Alonzo, Victor; Jaramillo, Claudia; Arias, William; Lozano, Rodrigo Barquera; Pérez, Gastón Macín; Gómez-Valdés, Jorge; Villamil-Ramírez, Hugo; Hunemeier, Tábita; Ramallo, Virginia; Silva de Cerqueira, Caio C.; Hurtado, Malena; Villegas, Valeria; Granja, Vanessa; Gallo, Carla; Poletti, Giovanni; Schuler-Faccini, Lavinia; Salzano, Francisco M.; Bortolini, Maria- Cátira; Canizales-Quinteros, Samuel; Cheeseman, Michael; Rosique, Javier; Bedoya, Gabriel; Rothhammer, Francisco; Headon, Denis; González-José, Rolando; Balding, David and Ruiz-Linares, Andrés
Nature Communications, 7, Article 11616


A genome-wide association study identifies multiple loci for variation in human ear morphology (2015)
Adhikari, Kaustubh; Reales, Guillermo; Smith, Andrew J. P.; Konka, Esra; Palmen, Jutta; Quinto-Sanchez, Mirsha; Acuña-Alonzo, Victor; Jaramillo, Claudia; Arias, William; Fuentes, Macarena; Pizarro, María; Barquera Lozano, Rodrigo; Macín Pérez, Gastón; Gómez-Valdés, Jorge; Villamil-Ramírez, Hugo; Hunemeier, Tábita; Ramallo, Virginia; Silva de Cerqueira, Caio C.; Hurtado, Malena; Villegas, Valeria; Granja, Vanessa; Gallo, Carla; Poletti, Giovanni; Schuler-Faccini, Lavinia; Salzano, Francisco M.; Bortolini, Maria- Cátira; Canizales-Quinteros, Samuel; Rothhammer, Francisco; Bedoya, Gabriel; Calderón, Rosario; Rosique, Javier; Cheeseman, Michael; Bhutta, Mahmood F.; Humphries, Steve E.; Gonzalez-José, Rolando; Headon, Denis; Balding, David and Ruiz-Linares, Andrés
Nature Communications, 6, Article 7500


Admixture in Latin America: Geographic Structure, Phenotypic Diversity and Self-Perception of Ancestry Based on 7,342 Individuals (2014)
Ruiz-Linares, Andrés; Adhikari, Kaustubh; Acuña-Alonzo, Victor; Quinto-Sanchez, Mirsha; Jaramillo, Claudia; Arias, William; Fuentes, Macarena; Pizarro, María; Everardo, Paola; de Avila, Francisco; Gómez-Valdés, Jorge; León-Mimila, Paola; Hunemeier, Tábita; Ramallo, Virginia; Silva de Cerqueira, Caio C.; Burley, Mari-Wyn; Konca, Esra; de Oliveira, Marcelo Zagonel; Veronez, Mauricio Roberto; Rubio-Codina, Marta; Attanasio, Orazio; Gibbon, Sahra; Ray, Nicolas; Gallo, Carla; Poletti, Giovanni; Rosique, Javier; Schuler-Faccini, Lavinia; Salzano, Francisco M.; Bortolini, Maria-Cátira; Canizales-Quinteros, Samuel; Rothhammer, Francisco; Bedoya, Gabriel; Balding, David and Gonzalez-José, Rolando
PLoS Genetics, 10(9) (e1004572)