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Dr Jon Golding

Profile summary

  • Central Academic Staff
  • Senior Lecturer in Health Sciences
  • Faculty of Science, Technology, Engineering & Mathematics
  • School of Life, Health & Chemical Sciences
  • jon.golding

Professional biography

I did my PhD research at King's College, London.

Post-doctoral positions at King's College London, Guy's Hospital, MRC National Institute for Medical Research, MRC Clinical Sciences Centre (Imperial).

MRC Collaborative Career Development Fellowship in Stem Cell Research.

Research interests

My lab works mainly on improving the effectiveness of the anti-cancer treatments photodynamic therapy (PDT) and radiotherapy. A full list of my research publications can be found at PubMed or Researchgate

A two-year clinical trial of our new combination PDT, in collaboration with the University of Cambridge, began in October 2013. On the basis of the excellent trial results, this has been adopted as a standard treatment option by Cambridge Veterinary School. 

PI. Clinical trial of combination photodynamic therapy for equine sarcoids . European Society for Veterinary Dermatology (2013-2015). €20k

PI. Mechanisms of nanoparticle toxicity in normal and tumour cells. Industrial funding (2015-2018). £68k

Co-I. Targeting radiotherapy with DNA binding metal complexes and their attachment to gold nanoparticles. Royal Society of Chemistry (2015). £5k

Co-I. EU Framework 7 grant PEOPLE-2013-ITN ARGENT- Advanced Radiotherapy, Generated by Exploiting Nanoprocesses and Technologies http://itn-argent.eu (2014-2017). £3.65M

Patent: Nanoparticles and their uses in medicine. GB1423049.4 (23/12/2014)

YouTube

Northampton Hospital

Northampton Chronicle

 

Currently we are looking to partner with clinicians and veterinary surgeons for a series of further clinical trials. Please contact Jon for further details.

Teaching interests

My main teaching interest is in developing global online life sciences education (e.g SK320 'infectious disease and public health').

SK320 module chair

Module author for S317 and S110

S210/S211/S212 module team

SXL390 module chair

External collaborations

I collaborate with:

  • Clinicians at Milton Keynes University Hospital and Northampton Hospital.
  • Veterinary surgeons at the University of Cambridge and Nottingham Trent University
  • Pharmaceutical companies (Midatech Pharma, Glaxo Smith Kline).
  • New University of Lisbon (RaBBiT program)

As chair of the Life and Biomolecular Sciences Management Group, I work to oversee PhD candidate training in OU Affiliated Research Centres (ARCs) around the world and to foster research relationships between ARCs.

Research Activity

Research groups

NameTypeParent Unit
Biomedical Research Network (BRN)NetworkFaculty of Science
Neuroscience Research GroupGroupFaculty of Science

 

Externally funded projects

Improving the efficiency and targeting of radiosensitisers

RoleStart dateEnd dateFunding source
Lead01/Feb/201731/Jan/2019Sir John Mason Academic Trust
New University of Lisbon have a doctoral training program called RaBBiT, whereby the student does research towards their PhD in a host lab (in this case at the OU). The student will be a visitor to the OU for 2 years. The Sir John Mason Academic Trust will meet the cost of the project specific consumables and expenses.

Mechanisms of nanoparticle toxicity

RoleStart dateEnd dateFunding source
Lead01/Oct/201530/Sep/2018Midatech Ltd
This is a matched funded PhD student project between LHCS and Midatech. This project will discover why certain nanoparticles are selectively toxic to different cell types.

Targeting radiotherapy with DNA binding metal complexes of amino acids.

RoleStart dateEnd dateFunding source
Other-collaborator06/Jul/201528/Aug/2015Royal Society of Chemistry (RSC)
This was to fund an undergraduate student, Kirsten Hawkins, who has approached the department for a summer placement.New approaches that localise radiosensitivity within tumours have the potential to improve the effectiveness of radiotherapy and reduce side effects for patients. Here we developed compounds, known as radiosensitisers, containing heavier elements such as metals that produce electrons upon radiotherapy. These electrons promote localised DNA damage in cancer cells leading to their death. Careful design of the complexes aimed to promote their localisation in the DNA of cancer cells so that those that these are most damaged upon radiotherapy. It is significant that we developed one copper containing compound that exhibited a comparatively low cytotoxicity in HEK293T cells (human embryonic kidney cells) over 24 h, for example it was approximately 45 times less cytotoxic to these cells in comparison to the anticancer drug cis-platin. This suggests its further study in targeted radiotherapy where the cytotoxicity in cancer cells would be turned on by the application of the radiotherapy. It is significant that we developed one copper containing compound that exhibited a comparatively low cytotoxicity in HEK293T cells (human embryonic kidney cells) over 24 h, for example it was approximately 45 times less cytotoxic to these cells in comparison to the anticancer drug cis-platin. This suggests its further study in targeted radiotherapy where the cytotoxicity in cancer cells would be turned on by the application of the radiotherapy. Abi Barbour, an A-S level student, also worked on this project under the Nuffield Research Placement scheme and as a result achieved her Gold Crest award.

Publications

Cancer-selective, single agent chemoradiosensitising gold nanoparticles (2017-07-10)
Grellet, Sophie; Tzelepi, Konstantina; Roskamp, Meike; Williams, Phil; Sharif, Aquila; Slade-Carter, Richard; Goldie, Peter; Whilde, Nicky; Smialek, Malgorzata A.; Mason, Nigel J. and Golding, Jon P.
PLoS ONE, 12, Article e0181103(7)
Glycolysis inhibition improves photodynamic therapy response rates for equine sarcoids (2017)
Golding, J. P.; Kemp-Symonds, J. G. and Dobson, J. M.
Veterinary and Comparative Oncology ((Early Access))
Gold nanoparticles for cancer radiotherapy: a review (2016-11-03)
Haume, Kaspar; Rosa, Soraia; Grellet, Sophie; Śmiałek, Małgorzata; Butterworth, Karl T.; Solov'yov, Andrey V.; Prise, Kevin M.; Golding, Jon and Mason, Nigel J.
Cancer Nanotechnology, 7(8)
Engineered neural tissue with aligned, differentiated adipose-derived stem cells promotes peripheral nerve regeneration across a critical sized defect in rat sciatic nerve. (2015-01)
Georgiou, Melanie; Golding, Jon P.; Loughlin, Alison J.; Kingham, Paul J. and Phillips, James B.
Biomaterials, 37 (pp. 242-251)
A 3D in vitro model reveals differences in the astrocyte response elicited by potential stem cell therapies for CNS injury. (2013-11-01)
East, Emma; Johns, Noémie; Georgiou, Melanie; Golding, Jon P.; Loughlin, A. Jane; Kingham, Paul J. and Phillips, James B.
Regenerative Medicine, 8(6) (pp. 739-746)
Engineered neural tissue for peripheral nerve repair (2013-10-01)
Georgiou, Melanie; Bunting, Stephen C. J.; Davies, Heather A.; Loughlin, Alison J.; Golding, Jonathan P. and Phillips, James B.
Biomaterials, 34(30) (pp. 7335-7343)
Targeting tumour energy metabolism potentiates the cytotoxicity of 5-aminolevulinic acid photodynamic therapy (2013-08-20)
Golding, J. P.; Wardhaugh, T.; Patrick, L.; Turner, M.; Phillips, J. B.; Bruce, J. I. and Kimani, S. G.
British Journal of Cancer, 109(4) (pp. 976-982)
Fully protected glycosylated zinc (II) phthalocyanine shows high uptake and photodynamic cytotoxicity in MCF-7 cancer cells (2013-01)
Kimani, Stanley; Shmigol, Tatiana; Hammond, Samantha; Phillips, James B.; Bruce, James I.; MacRobert, Alexander J.; Malakhov, Mikhail V. and Golding, Jon P.
Photochemistry and Photobiology, 89(1) (pp. 139-149)
Engineering an integrated cellular interface in three-dimensional hydrogel cultures permits monitoring of reciprocal astrocyte and neuronal responses (2012-07-11)
East, Emma; Golding, Jon P. and Phillips, James B.
Tissue Engineering Part C: Methods, 18(7) (pp. 526-536)
Regulation of PP2A activity by Mid1 controls cranial neural crest speed and gangliogenesis (2012-01)
Latta, Elizabeth J. and Golding, Jon P.
Mechanisms of Development, 128(11-12) (pp. 560-576)
Alignment of astrocytes increases neuronal growth in three-dimensional collagen gels and is maintained following plastic compression to form a spinal cord repair conduit (2010-10-01)
East, Emma; Blum de Oliveira, Daniela; Golding, Jon P. and Phillips, James B.
Tissue Engineering Part A, 16(10) (pp. 3173-3184)
Homing of stem cells to sites of inflammatory brain injury after intracerebral and intravenous administration: a longitudinal imaging study (2010-06)
Jackson, Johanna S.; Golding, Jon P.; Chapon, Catherine; Jones, William A. and Bhakoo, Kishore K.
Stem Cells Research & Therapy, 1(2) (pp. 1-17)
A versatile 3D culture model facilitates monitoring of astrocytes undergoing reactive gliosis (2009-10)
East, Emma; Golding, Jonathan P. and Phillips, James B.
Journal of Tissue Engineering and Regenerative Medicine, 3(8) (pp. 634-646)
Astrocyte alignment increases neurite outgrowth in a 3D cell culture model (2009)
East, Emma; Blum de Oliveira, Daniela; Golding, Jon and Phillips, James
Glia, 57(S13) (S159)
Developing a 3D culture model of CNS myelination (2009)
Loughlin, Jane; East, Emma; Golding, Jon and Phillips, James
Glia, 57(S13) (S119)
Skeletal muscle stem cells express anti-apoptotic ErbB receptors during activation from quiescence (2007-01-15)
Golding, Jon P; Calderbank, Emma; Partridge, Terence and Beauchamp, Jonathan
Experimental Cell Research, 313(2) (pp. 341-356)
Development of a 3-dimensional in vitro model to study reactive gliosis following nervous system injury (2007)
East, Emma; Golding, Jon and Phillips, James
Tissue Engineering, 13(7) (pp. 1668-1668)
Increased GFAP immunoreactivity by astrocytes in response to contact with dorsal root ganglia cells in a 3D culture model (2007)
East, Emma; Golding, Jon and Phillips, James
Neuron Glia Biology, 3(S1) (S119)
Mouse myotomes pairs exhibit left-right asymmetric expression of MLC3F and α-skeletal actin (2004-12)
Golding, Jon P.; Partridge, Terence A.; Beauchamp, Jonathan R.; King, Tim; Brown, Nigel A.; Gassmann, Martin and Zammit, Peter S.
Developmental Dynamics, 231(4) (pp. 795-800)
Heparin-binding EGF-like growth factor shows transient left-right asymmetrical expression in mouse myotome pairs (2004-11)
Golding, Jon P.; Tsoni, Stavroula; Dixon, Monica; Yee, Kathleen T.; Partridge, Terence A.; Beauchamp, Jonathan R.; Gassmann, Martin and Zammit, Peter S.
Gene Expression Patterns, 5(1) (pp. 3-9)
Myf5 expression in satellite cells and spindles in adult muscle is controlled by separate genetic elements (2004-09-15)
Zammit, Peter S.; Carvajal, Jaime J.; Golding, Jon P.; Morgan, Jennifer E.; Summerbell, Dennis; Zolnerciks, Joseph; Partridge, Terence A.; Rigby, Peter W.J. and Beauchamp, Jonathan R.
Developmental Biology, 273(2) (pp. 454-465)
Muscle satellite cells adopt divergent fates: a mechanism for self-renewal? (2004-08-02)
Zammit, Peter S.; Golding, Jon P.; Nagata, Yosuke; Hudon, Valerie; Partridge, Terence A. and Beauchamp, Jonathan R.
Journal of Cell Biology, 166(3) (pp. 347-357)
Roles of erbB4, rhombomere-specific, and rhombomere-independent cues in maintaining neural crest-free zones in the embryonic head (2004-02-15)
Golding, Jon P.; Sobieszczuk, Dorothy; Dixon, Monica; Coles, Edward; Christiansen, Jeff; Wilkinson, David and Gassmann, Martin
Developmental Biology, 266(2) (pp. 361-372)
ErbB4 signaling during breast and neural development: novel genetic models reveal unique ErbB4 activities (2003-11)
Jones, Frank E.; Golding, Jon P. and Gassmann, Martin
Cell Cycle, 2(6) (pp. 555-559)
Neural and mammary gland defects in ErbB4 knockout mice genetically rescued from embryonic lethality (2003-07-08)
Tidcombe, Hester; Jackson-Fisher, Amy; Mathers, Kathleen; Stern, David F.; Gassmann, Martin and Golding, Jon P.
Proceedings of the National Academy of Sciences of the United States of America, 100(14) (pp. 8281-8286)
Cues from neuroepithelium and surface ectoderm maintain neural crest-free regions within cranial mesenchyme of the developing chick (2002-03-01)
Golding, Jon P.; Dixon, Monica and Gassmann, Martin
Development, 129(5) (pp. 1095-1105)
New Research in Ionizing Radiation and Nanoparticles: The ARGENT Project (2016-12-16)
Bolsa Ferruz, M.; Ivošev, V.; Haume, K.; Ellis-Gibbings, L.; Traore, A.; Thakare, V.; Rosa, S.; de Vera, Pablo; Tran, V.-L.; Mika, A.; Boscolo, D.; Grellet, S.; Verkhovtsev, Alexey; Huber, Bernd A.; Butterworth, K. T.; Prise, K. M.; Currell, F. J.; Mason, Nigel J.; Golding, J.; Scifoni, E.; Garcia, Gustavo; Boschetti, F.; Lux, F.; Tillement, O.; Louis, C.; Stokbro, K.; Solov'yov, Andrey V. and Lacombe, S.
In: Solov'yov, Andrey V. ed. Nanoscale insights into ion-beam cancer therapy (pp. 379-434)
ISBN : 978-3-319-43030-0 | Publisher : Springer International Publishing | Published : Cham
Cancer-selective toxicity of gold nanoparticles: effects of synthesis time and charge (2016-06-27)
Tzelepi, Nadia and Golding, Jon
In : CLINAM 2016 (26-29 June 2016, Basel, Switzerland)
Selective cancer cell toxicity and radiosensitization using different high atomic number nanoparticles (2016-06-02)
Grellet, S.; Kaas, S.; Crabb, E.; Allman, S. and Golding, J.
In : Nanotech France 2016 (1-3 June 2016, Paris, France)
Selective cancer cell toxicity and radiosensitization with gold nanoparticles (2015-10-19)
Grellet, Sophie; Williams, Phil and Golding, Jon
In : Advances in nanoparticulate carriers: Applications in diseases and infections (19-21 October 2015, Institut Pasteur, Paris)
Fabrication of an endoneurium using engineered neural tissue within a peripheral nerve repair conduit (2013-06)
Georgiou, Melanie; Golding, Jon; Loughlin, Jane and Phillips, James
In : Tissue Engineering and Regenerative Medicine International Society - EU Meeting (17-20 June 2013, Istanbul, Turkey)
A living replacement tissue for peripheral nerve that can enhance regeneration in vitro and in vivo (2012-09)
Georgiou, Melanie; Bunting, Stephen; Golding, Jon; Loughlin, Jane and Phillips, James
In : Tissue Engineering and Regenerative Medicine International Society - World Congress 2012 (5 - 8 September 2012, Vienna, Austria)
A nerve repair conduit containing differentiated adipose-derived stem cells within engineered neural tissue can support and guide neuronal growth in vitro and in vivo (2012-09)
Georgiou, Melanie; Kingham, Paul; Bunting, Stephen; Golding, Jon; Loughlin, Jane and Phillips, James
In : Tissue Engineering and Regenerative Medicine International Society - World Congress 2012 (5 - 8 September 2012, Vienna, Austria)
Astrocytes expressing GFP in 3D collagen gels provide an effective model for screening the glial response to potential CNS cell therapies (2012-07)
Johns, N.; East, E.; Golding, J. P.; Loughlin, A. J. and Phillips, J. B.
In : Annual meeting of the Tissue and Cell Engineering Society (TCES) (4-6 July 2012, Liverpool, UK)
Engineered neural tissue with aligned Schwann cells supports neuronal regeneration in vivo and can be assembled using differentiated adipose-derived stem cells (2012-07)
Georgiou, M.; Loughlin, J.; Golding, J. P.; Kingham, P. J. and Phillips, J. B.
In : Annual meeting of the Tissue and Cell Engineering Society (TCES) (4-6 July 2012, Liverpool, UK)
Engineered neural tissue with columns of aligned Schwann cell-like cells from differentiated adipose-derived stem cells can support and guide neuronal growth in vitro (2012-04)
Georgiou, Melanie; Kingham, Paul; Golding, Jon; Loughlin, Jane and Phillips, James
In : 3rd International Conference on Stem Cell Engineering "Designing Cellular Therapies" (29 April - 02 May 2012, Seattle, US)
Aligned Schwann cells within 3D tissue-like gels provide guidance to regenerating neurites (2011-09)
Georgiou, M.; East, E.; Loughlin, J.; Golding, J. and Phillips, J.
In : 10th European Meeting on Glial Cells in Health and Disease (13-17 September 2011, Prague, Czech Republic)
Aligned cellular and acellular collagen guidance substrates for peripheral nerve repair (2011-07)
Georgiou, Melanie; Loughlin, Jane; Golding, Jon and Phillips, James
In : Tissue and Cell Engineering Society (19 - 21 July 2011, Leeds)
A tissue engineered collagen conduit containing columns of aligned Schwann cells supports neuronal regeneration in vitro (2011)
Georgiou, M.; East, E.; Loughlin, A. J.; Golding, J. P. and Phillips, J. B.
In : 2011 PNS Biennial Meeting of the Peripheral Nerve Society (25-29 June 2011, Potomac, Maryland, US)
Development of an integrated collagen gel system for studying cellular interfaces following spinal cord injury (2010-07)
East, E.; Golding, J.P. and Phillips, J.B.
In : Tissue and Cell Engineering Society (28-30th July, Manchester, U.K.)
Schwann cells in collagen gels survive plastic compression and maintain their alignment: development of a cellular biomaterial for peripheral nerve repair (2010-07)
Georgiou, M.; East, E.; Loughlin, J.; Golding, J.P. and Phillips, J.B.
In : Tissue and Cell Engineering Society (28-30th July, Manchester, U.K.)
Plastic compression of aligned cellular collagen gels for nervous system repair (2010-06)
East, E.; Georgiou, M.; Loughlin, A.J.; Golding, J.P. and Phillips, J.B.
In : Tissue Engineering and Regenerative Medicine International Society - EU Meeting (13-17th June, Galway, Ireland)
Potentiation of AlPcS2 mediated photodynamic therapy by energy metabolism inhibitors in human tumour cell lines (2009-09-05)
Kimani, Stanley; Phillips, James; Bruce, James; MacRobert, A. J. and Golding, Jon
In : 13th Congress of the European Society for Photobiology (5 Sep 2009, Warsaw, Poland)
Astrocyte alignment in 3D collagen gels increases neurite outgrowth; implications for improving spinal cord repair (2009-07)
East, E.; Blum de Oliveira, D.; Golding, J. P. and Phillips, J. B.
In : Tissue and Cell Engineering Society (8-10th July 2009, Glasgow) (pp. 13-13)
Monitoring reactive gliosis in 3-dimensional astrocyte cultures; a model of spinal cord damage (2008-11-19)
Phillips, James; East, Emma and Golding, Jon
In : Neuroscience 2008: 38th annual meeting of the Society for Neuroscience (15-19 Nov 2008, Washington, DC)
Glucosamine improves the efficiency of photodynamic therapy (PDT) (2008-10-07)
Kimani, Stanley; Phillips, James; Bruce, James; MacRobert, A. J and Golding, Jon
In : Photodynamic Therapy and Photodiagnosis in Clinical Practice (7- 11 Oct 2008, Brixen, Italy)
Modelling the injured spinal cord using 3-dimensional cell cultures; strategies for improving tissue engineered repair (2008)
East, E.; Golding, J. P. and Phillips, J. B.
In : Annual meeting of the Tissue and Cell Engineering Society (TCES) (2-4 July 2008, University of Nottingham, UK) (p 51)
Midline1 and the development of the cranial peripheral nervous system (2008)
Latta, Elizabeth; Saffrey, Jill and Golding, Jon
In : Joint meeting of the British and Spanish Developmental Biology Societies (24-27 Sep 2008, Seville, Spain)
Modelling of the injured spinal cord using 3-dimensional cell cultures; strategies for improving tissue engineered repair (2007-11-06)
East, E.; Golding, J.P. and Phillips, J.B.
In : Society for Neuroscience (3-7 Nov 2007, San Diego, California)
An in vivo model of epidermal neural crest cell migration after implantation into the brain (2007-11-04)
Jackson, J.S.; Golding, J.; Chapon, C.; Jones, W. and Bhakoo, K.K.
In : Society for Neuroscience (3-7 Nov 2007, San Diego, California)
Development of a 3-dimensional in vitro model to study reactive gliosis following nervous system injury (2007-07)
East, Emma; Golding, Jon and Phillips, James
In : Tissue Engineering - EU Chapter meeting 2007 (4-7 September 2007, London, UK) (pp. 1668-1778)
Increased GFAP immunoreactivity by astrocytes in response to contact with dorsal root ganglia cells in a 3D culture model (2007)
East, Emma; Golding, Jon and Phillips, James
In : Glial cells in health and disease (4-8 September 2007, London, UK)
Maintaining the regenerative compartment of adult skeletal muscle (2005-05-09)
Beauchamp, J.R.; Zammit, P.S.; Nagata, Y.; Golding, J. and Partridge, T.A.
In : Congress of Myology (09-13 May 2005, Nantes, France)
Not all activated satellite cell progeny commit to differentiation (2003-09)
Golding, J.P.; Beauchamp, J.R.; Partridge, T.A. and Zammit, P.S.
In : 32nd European Muscle Conference (7-10 Sep 2003, Montpellier, France)

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