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Dr Christopher Heath

Research Activity

Externally funded projects

TRANSFER IN: Development and validation of a rodent touchscreen battery for assessing motivation and affective state

RoleStart dateEnd dateFunding source
Lead01/Apr/201631/Mar/2019NC3Rs (National Centre for the Replacement Refinement and Reduction of Animals in Research)
The focus of this project is to develop and validate a series of non-invasive behavioural assessments for laboratory rodents that will enable routine evaluation of motivation and affective state. These assays will be designed with a lower severity band (refinement) and require fewer animals (reduction) than current methods.

Publications

Optimisation of cognitive performance in rodent operant (touchscreen) testing: Evaluation and effects of reinforcer strength (2017-02-15)
Phillips, Benjamin U.; Heath, Christopher J.; Ossowska, Zofia; Bussey, Timothy J. and Saksida, Lisa M.
Learning and Behavior ((Early Access))
A mouse model of the 15q13.3 microdeletion syndrome shows prefrontal neurophysiological dysfunctions and attentional impairment. (2016-03-17)
Nilsson, Simon R. O.; Celada, Pau; Fejgin, Kim; Thelin, Jonas; Nielsen, Jacob; Santana, Noemí; Heath, Christopher J.; Larsen, Peter H.; Nielsen, Vibeke; Kent, Brianne A.; Saksida, Lisa M.; Stensbøl, Tine B.; Robbins, Trevor W.; Bastlund, Jesper F.; Bussey, Timothy J.; Artigas, Francesc and Didriksen, Michael
Psychopharmacology
An epigenetic mechanism mediates developmental nicotine effects on neuronal structure and behavior (2016)
Jung, Yonwoo; Hsieh, Lawrence S.; Lee, Angela M.; Zhou, Zhifeng; Coman, Daniel; Heath, Christopher J.; Hyder, Fahmeed; Mineur, Yann S; Yuan, Qiaoping; Goldman, David; Bordey, Angelique and Picciotto, Marina R
Nature Neuroscience, 19(7) (pp. 905-914)
Motivational assessment of mice using the touchscreen operant testing system: effects of dopaminergic drugs (2015-11-01)
Heath, Christopher J.; Bussey, Timothy J. and Saksida, Lisa M.
Psychopharmacology, 232(21) (pp. 4043-4057)
Facilitation of spatial working memory performance following intra-prefrontal cortical administration of the adrenergic alpha1 agonist phenylephrine. (2015-11)
Hvoslef-Eide, Martha; Oomen, C. A.; Fisher, B. M.; Heath, C. J.; Robbins, T. W.; Saksida, L. M. and Bussey, T. J.
Psychopharmacology, 232(21) (pp. 4005-4016)
The role of the dorsal hippocampus in two versions of the touchscreen automated paired associates learning (PAL) task for mice. (2015-11)
Kim, Chi Hun; Heath, Christopher J.; Kent, Brianne A.; Bussey, Timothy J. and Saksida, Lisa M.
Psychopharmacology, 232(21) (pp. 3899-3910)
Trial-unique, delayed nonmatching-to-location (TUNL) touchscreen testing for mice: sensitivity to dorsal hippocampal dysfunction. (2015-11)
Kim, Chi Hun; Romberg, Carola; Hvoslef-Eide, Martha; Oomen, Charlotte A.; Mar, Adam C.; Heath, Christopher J.; Berthiaume, Andrée-Anne; Bussey, Timothy J. and Saksida, Lisa M.
Psychopharmacology, 232(21) (pp. 3935-3945)
The NEWMEDS rodent touchscreen test battery for cognition relevant to schizophrenia (2015-07-24)
Hvoslef-Eide, M.; Mar, A. C.; Nilsson, S. R. O.; Alsiö, J.; Heath, C. J.; Saksida, L. M.; Robbins, T. W. and Bussey, T. J.
Psychopharmacology
The touchscreen operant platform for testing learning and memory in rats and mice. (2013-10)
Horner, Alexa E.; Heath, Christopher J.; Hvoslef-Eide, Martha; Kent, Brianne A.; Kim, Chi Hun; Nilsson, Simon R. O.; Alsiö, Johan; Oomen, Charlotte A.; Holmes, Andrew; Saksida, Lisa M. and Bussey, Timothy J.
Nature Protocols, 8(10) (pp. 1961-84)
The touchscreen operant platform for testing working memory and pattern separation in rats and mice. (2013-10)
Oomen, Charlotte A.; Hvoslef-Eide, Martha; Heath, Christopher J.; Mar, Adam C.; Horner, Alexa E.; Bussey, Timothy J. and Saksida, Lisa M.
Nature Protocols, 8(10) (pp. 2006-2021)
False recognition in a mouse model of Alzheimer's disease: rescue with sensory restriction and memantine. (2012-07)
Romberg, Carola; McTighe, Stephanie M.; Heath, Christopher J.; Whitcomb, Daniel J.; Cho, Kwangwook; Bussey, Timothy J. and Saksida, Lisa M.
Brain : a journal of neurology, 135(7) (pp. 2103-2114)
Impaired auditory discrimination learning following perinatal nicotine exposure or β2 nicotinic acetylcholine receptor subunit deletion (2012-05-16)
Horst, Nicole K.; Heath, Christopher J.; Neugebauer, Nichole M.; Kimchi, Eyal Y.; Laubach, Mark and Picciotto, Marina R.
Behavioural Brain Research, 231(1) (pp. 170-180)
Oral nicotine consumption does not affect maternal care or early development in mice but results in modest hyperactivity in adolescence. (2010-12-02)
Heath, Christopher J.; Horst, Nicole K. and Picciotto, Marina R.
Physiology & behavior, 101(5) (pp. 764-769)
Cortico-Thalamic Connectivity is Vulnerable to Nicotine Exposure During Early Postnatal Development through α4/β2/α5 Nicotinic Acetylcholine Receptors (2010-11)
Heath, Christopher J.; King, Sarah L.; Gotti, Cecilia; Marks, Michael J. and Picciotto, Marina R.
Neuropsychopharmacology, 35(12) (pp. 2324-2338)
Allelic variation of calsyntenin 2 (CLSTN2) modulates the impact of developmental tobacco smoke exposure on mnemonic processing in adolescents. (2009-04-15)
Jacobsen, Leslie K.; Picciotto, Marina R.; Heath, Christopher J.; Mencl, W. Einar and Gelernter, Joel
Biological Psychiatry, 65(8) (pp. 671-679)
Nicotine-induced plasticity during development: modulation of the cholinergic system and long-term consequences for circuits involved in attention and sensory processing. (2009)
Heath, Christopher J. and Picciotto, Marina R.
Neuropharmacology, 56(Sup 1) (pp. 254-262)
Prenatal and Adolescent Exposure to Tobacco Smoke Modulates the Development of White Matter Microstructure (2007-12-05)
Jacobsen, Leslie K.; Picciotto, Marina R.; Heath, Christopher; Frost, Stephen J.; Tsou, Kristen A.; Dwan, Rita A.; Jackowski, Marcel P.; Constable, Robert T. and Mencl, W. Einar
The Journal of Neuroscience , 27(49) (pp. 13491-13498)
Nicotine-induced phosphorylation of ERK in mouse primary cortical neurons: evidence for involvement of glutamatergic signaling and CaMKII. (2007-10)
Steiner, Rebecca C.; Heath, Christopher J. and Picciotto, Marina R.
Journal of Neurochemistry, 103(2) (pp. 666-78)
Measuring Motivation and Reward-Related Decision Making in the Rodent Operant Touchscreen System. (2016-01-04)
Heath, Christopher J.; Phillips, Benjamin U.; Bussey, Timothy J. and Saksida, Lisa M.
In: Gerfen, Charles R.; Holmes, Andrew; Sibley, David; Skolnick, Phil and Wray, Susan eds. Current Protocols in Neuroscience (pp. 8.34.1-8.34.20)
ISBN : 9780471142300 | Publisher : John Wiley & Sons | Published : Chichester

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